Pyridoxal kinase and poly(ADP-ribose) affect the immune microenvironment of locally advanced cancers - Sorbonne Université
Journal Articles OncoImmunology Year : 2021

Pyridoxal kinase and poly(ADP-ribose) affect the immune microenvironment of locally advanced cancers

Abstract

Malignant cells adapt to the hostile tumor microenvironment by escaping from, or actively suppressing, anticancer immune responses. In the past, we reported that reduced synthesis of active vitamin B6 (due to downregulation of pyridoxal kinase) or overactivation of poly(ADP-ribose) polymerase confers resistance to chemotherapy with cisplatin. Recently, we found that these prognostically adverse alterations in oncometabolism also correlate with the rarefaction of immune effectors in the tumor bed.
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Dates and versions

hal-03342400 , version 1 (13-09-2021)

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Adrien Joseph, Juncheng Pan, Judith Michels, Guido Kroemer, Maria Castedo. Pyridoxal kinase and poly(ADP-ribose) affect the immune microenvironment of locally advanced cancers. OncoImmunology, 2021, 10 (1), pp.1950954. ⟨10.1080/2162402x.2021.1950954⟩. ⟨hal-03342400⟩
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