How can polyreactive antibodies conquer rapidly evolving viruses?
Abstract
Broadly neutralizing antibodies against rapidly-evolving viruses (e.g. HIV-1 and influenza virus), often manifest antigen-binding promiscuity. Based on a recent study, we hypothesize on the significance of antibody polyreactivity in neutralization of rapidly-evolving viruses. We propose that polyreactivity contributes to tolerate viral variants and shortens time for appearance of neutralizing antibodies.
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