How can polyreactive antibodies conquer rapidly evolving viruses? - Sorbonne Université
Article Dans Une Revue Trends in Immunology Année : 2021

How can polyreactive antibodies conquer rapidly evolving viruses?

Alejandra Reyes-Ruiz
Jordan D Dimitrov

Résumé

Broadly neutralizing antibodies against rapidly-evolving viruses (e.g. HIV-1 and influenza virus), often manifest antigen-binding promiscuity. Based on a recent study, we hypothesize on the significance of antibody polyreactivity in neutralization of rapidly-evolving viruses. We propose that polyreactivity contributes to tolerate viral variants and shortens time for appearance of neutralizing antibodies.
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Dates et versions

hal-03344263 , version 1 (14-09-2021)

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Alejandra Reyes-Ruiz, Jordan D Dimitrov. How can polyreactive antibodies conquer rapidly evolving viruses?. Trends in Immunology, 2021, 42 (8), pp.654-657. ⟨10.1016/j.it.2021.06.008⟩. ⟨hal-03344263⟩
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