Genetic variation near CXCL12 is associated with susceptibility to HIV-related non-Hodgkin lymphoma - Sorbonne Université
Journal Articles Haematologica Year : 2021

Genetic variation near CXCL12 is associated with susceptibility to HIV-related non-Hodgkin lymphoma

Ioannis Theodorou
Charles S Rabkin
  • Function : Author

Abstract

Human immunodeficiency virus (HIV) infection is associated with an increased risk of non-Hodgkin lymphoma (NHL). Even in the era of suppressive antiretroviral treatment, HIV-infected individuals remain at higher risk of developing NHL compared to the general population. To identify potential genetic risk loci, we performed case-control genome-wide association studies and a meta-analysis across three cohorts of HIV+ patients of European ancestry, including a total of 278 cases and 1924 matched controls. We observed a significant association with NHL susceptibility in the C-X-C motif chemokine ligand 12 (CXCL12) region on chromosome 10. A fine mapping analysis identified rs7919208 as the most likely causal variant (P = 4.77e-11), with the G>A polymorphism creating a new transcription factor binding site for BATF and JUND. These results suggest a modulatory role of CXCL12 regulation in the increased susceptibility to NHL observed in the HIV-infected population.

Domains

Hematology
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Origin Publication funded by an institution

Dates and versions

hal-03368950 , version 1 (07-10-2021)

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Christian W Thorball, Tiphaine Oudot-Mellakh, Nava Ehsan, Christian Hammer, Federico A Santoni, et al.. Genetic variation near CXCL12 is associated with susceptibility to HIV-related non-Hodgkin lymphoma. Haematologica, 2021, 106 (8), pp.2233-2241. ⟨10.3324/haematol.2020.247023⟩. ⟨hal-03368950⟩
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