Tryptophan, an Amino-Acid Endowed with Unique Properties and Its Many Roles in Membrane Proteins - Sorbonne Université
Journal Articles Crystals Year : 2021

Tryptophan, an Amino-Acid Endowed with Unique Properties and Its Many Roles in Membrane Proteins

Sonia Khemaissa
  • Function : Author
  • PersonId : 1112558
  • IdRef : 276721446
Sandrine Sagan
Astrid Walrant

Abstract

Tryptophan is an aromatic amino acid with unique physico-chemical properties. It is often encountered in membrane proteins, especially at the level of the water/bilayer interface. It plays a role in membrane protein stabilization, anchoring and orientation in lipid bilayers. It has a hydrophobic character but can also engage in many types of interactions, such as π–cation or hydrogen bonds. In this review, we give an overview of the role of tryptophan in membrane proteins and a more detailed description of the underlying noncovalent interactions it can engage in with membrane partners.
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Dates and versions

hal-03369294 , version 1 (07-10-2021)

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Sonia Khemaissa, Sandrine Sagan, Astrid Walrant. Tryptophan, an Amino-Acid Endowed with Unique Properties and Its Many Roles in Membrane Proteins. Crystals, 2021, 11 (9), pp.1032. ⟨10.3390/cryst11091032⟩. ⟨hal-03369294⟩
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