Crizotinib and ceritinib trigger immunogenic cell death via on-target effects
Résumé
Immunogenic cell death (ICD) has initially been discovered in the context of chemotherapy. High-dose crizotinib also stimulates ICD, as we described for non-small cell lung cancer lacking activating chromosomal aberrations of ALK or ROS1, the usual targets of crizotinib, indicating that crizotinib may act through off-target effects. However, we found that low-dose of ALK inhibitors, crizotinib and ceritinib, may stimulate ICD in anaplastic large cell lymphoma, in which ALK is activated due to a chromosomal translocation, suggesting on target ICD-promoting effects.
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Sciences du Vivant [q-bio]
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Crizotinib and ceritinib trigger immunogenic cell death via on target effects.pdf (948.07 Ko)
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