Recent breakthroughs in biotechnology are rising the demand for single-cell manipulation techniques such as cell isolation and 3D orientation. Significant challenges remain for these applications, mainly due to the physics involved and the size constraints imposed by the environment. The precision required at those dimensions have a cost in term of workspace, grasping strategies and control schemes. Furthermore, there is an increasing demand to manipulate objects in confined environments like micro-fluidic devices, rendering external actuators unusable. In this presentation, an interactive optical robotic system is introduced. It implements unthetered actuation and wireless sensing for microobjects in a confined liquid medium.