While developed in a number of directions, bioinspired catalysis has been explored only very recently for CO2 reduction, a challenging reaction, of prime importance in the context of the energetic transition to be built up. This approach is particularly relevant as Nature teaches us that CO2 reduction is possible, with low overpotentials, high rates and large selectivity, and gives us unique clues to design and discover new interesting molecular catalysts. Indeed, based on our relatively advanced understanding of the structures and mechanisms of the active sites of fascinating metalloenzymes such as formate dehydrogenases (FDHs) and CO dehydrogenases (CODHs), it is possible to design original, active, selective and stable, molecular catalysts using the bioinspired