COVID-19 and CAR-T cells: current challenges and future directions-a report from the EPICOVIDEHA survey by EHA-IDWP - Sorbonne Université
Journal Articles Blood Advances Year : 2021

COVID-19 and CAR-T cells: current challenges and future directions-a report from the EPICOVIDEHA survey by EHA-IDWP

Alessandro Busca
Alba Cabirta
Roberta Di Blasi
Remy Dulery
Francesca Farina
Barbora Weinbergerová
Josip Batinić
Anna Nordlander
Alberto Lopez-Garcia
Lubos Drgona
Ildefonso Espigado
Iker Falces-Romero
Ramon Garcia-Sanz
Carolina Garcia-Vidal
Anna Guidetti
Nina Khanna
Austin Kulesekararaj
Johan Maertens
Martin Hoenigl
Nikolai Klimko
Philipp Koehler
Antonio Pagliuca
Francesco Passamonti
Oliver Cornely
Livio Pagano
Ambu Gmbh
  • Function : Author
Astellas Pharma
  • Function : Author

Abstract

Patients receiving chimeric antigen receptor T cells (CAR-T cells) therapy may be particularly susceptible to coronavirus disease 2019 (COVID-19) because of several factors including the immunosuppression associated to the underlying disease and delayed cytopenias. Regrettably, data on outcomes of CART recipients with COVID-19 are extremely scarce. The aim of this study was to investigate the characteristics and outcomes of COVID-19 in patients treated with CART therapy. The European Hematology Association-Scientific Working Group Infection in Hematology endorsed a survey to collect and analyze data from patients developing COVID-19 after CART therapy. Overall, 459 patients treated with CART cells were reported from 18 European centers. The prevalence of COVID-19 cases was 4.8%. Median time from CART therapy and COVID-19 diagnosis was 169 days. Severe infection occurred in 66.7% of patients and 43.3% of the subjects required admission to ICU. The COVID-19 mortality was 33%. In multivariable analysis, the disease status at the time of COVID-19 trended marginally towards adverse outcome (P=0.075). In conclusion, we documented a high fatality rate for CART patients with COVID-19, supporting the need to design successful interventions to mitigate the risk of infection in this vulnerable group of patients.
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hal-03430350 , version 1 (16-11-2021)

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Alessandro Busca, Jon Salmanton-García, Paolo Corradini, Francesco Marchesi, Alba Cabirta, et al.. COVID-19 and CAR-T cells: current challenges and future directions-a report from the EPICOVIDEHA survey by EHA-IDWP. Blood Advances, 2021, ⟨10.1182/bloodadvances.2021005616/1833925/bloodadvances.2021005616.pdf⟩. ⟨hal-03430350⟩
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