The wide spectrum of COVID-19 neuropsychiatric complications within a multidisciplinary centre - Sorbonne Université
Journal Articles Brain Communications Year : 2021

The wide spectrum of COVID-19 neuropsychiatric complications within a multidisciplinary centre

Cécile Delorme (1) , Marion Houot (2) , Charlotte Rosso (1) , Stéphanie Carvalho (1) , Thomas Nedelec (1) , Redwan Maatoug (2) , Victor Pitron (2) , Salimata Gassama (2) , Sara Sambin (2) , Stéphanie Bombois (2) , Bastien Herlin (2) , Gaëlle Ouvrard (3) , Gaëlle Bruneteau (4, 2) , Adèle Hesters (2) , Ana Zenovia Gales (2) , Bruno Millet (2, 1) , Foudil Lamari (2) , Stéphane Lehericy (1, 2) , Vincent Navarro (1, 2) , Benjamin Rohaut (1, 2) , Sophie Demeret (2) , Thierry Maisonobe (2, 2) , Marion Yger (5) , Bertrand Degos (2) , Louise-Laure Mariani (2, 1) , Christophe Bouche (2) , Nathalie Dzierzynski (6) , Bruno Oquendo (2) , Flora Ketz (2) , An-Hung Nguyen (2) , Aurélie Kas (2) , Catherine Lubetzki (2, 1) , Jean-Yves Delattre (1) , Jean-Christophe Corvol (1, 2) , Bertrand Fontaine (1) , Philippe Thoumie , Tarek Sharshar , Sonia Alamowitch , Emmanuelle Apartis-Bourdieu , Charles-Siegried Peretti , Renata Ursu , Kiyoka Kinugawa Bourron , Joel Belmin , Eric Pautas , Marc Verny , Yves Samson , Sara Leder , Anne Leger , Sandrine Deltour , Flore Baronnet , Mehdi Touat , Marc Sanson , Caroline Dehais , Caroline Houillier , Florence Laigle-Donadey , Dimitri Psimaras , Agusti Alenton , Nadia Younan , Nicolas Villain , Maria del Mar Amador , Nicolas Mezouar , Graziella Mangone , Aurelie Meneret , Andreas Hartmann , Clement Tarrano , David Bendetowicz , Pierre-François Pradat , Michel Baulac , Phintip Pichit , Florence Chochon , an Hung Nguyen , Valerie Porcher , Alexandre Demoule , Elise Morawiec , Julien Mayaux , Morgan Faure , Claire Ewenczyk , Giulia Coarelli , Anna Heinzmann , Marion Masingue , Guillaume Bassez , Isabelle An , Yulia Worbe , Virginie Lambrecq , Rabab Debs , Esteban Munoz Musat , Timothee Lenglet , Aurelie Hanin , Lydia Chougar , Nathalia Shor , Nadya Pyatigorskaya , Damien Galanaud , Delphine Leclercq , Albert Cao , Clemence Marois , Nicolas Weiss , Loic Le Guennec , Vincent Degos , Alice Jacquens , Thomas Similowski , Capucine Morelot-Panzini , Jean-Yves Rotge , Bertrand Saudreau , Nassim Sarni , Nathalie Girault , Smaranda Leu , Lionel Thivard , Karima Mokhtari , Isabelle Plu , Bruno Gonçalves , Laure Bottin , Rebecca Haddad , Carmelo Lafuente , Christel Oasi , Bruno Megabarne , Dominique Herve , Haysam Salman , Armelle Rametti-Lacroux , Alize Chalançon , Anais Herve , Hugo Royer , Florence Beauzor , Valentine Maheo , Christelle Laganot , Camille Minelli , Aurelie Fekete , Abel Grine , Marie Biet , Rania Hilab , Aurore Besnard , Meriem Bouguerra , Gwen Goudard , Saida Houairi , Saba Al-Youssef , Christine Pires , Anissa Oukhedouma , Katarzyna Siuda-Krzywicka , Tal Seidel Malkinson , Hanane Agguini , Safia Said , Ana Zenovia Gales , Vanessa Batista Brochard , Kiyoka Kinugawa Bourron , An Hung Nguyen , Esteban Munoz Musat , Tal Seidel Malkinson
Sara Sambin
Bastien Herlin
Ana Zenovia Gales
Foudil Lamari
Philippe Thoumie
  • Function : Author
  • PersonId : 1381264
  • IdRef : 031340849
Tarek Sharshar
  • Function : Author
Sonia Alamowitch
  • Function : Author
Emmanuelle Apartis-Bourdieu
  • Function : Author
Charles-Siegried Peretti
  • Function : Author
Renata Ursu
  • Function : Author
Kiyoka Kinugawa Bourron
  • Function : Author
Joel Belmin
Eric Pautas
  • Function : Author
Marc Verny
  • Function : Author
Yves Samson
  • Function : Author
Sara Leder
  • Function : Author
Anne Leger
  • Function : Author
Sandrine Deltour
  • Function : Author
Flore Baronnet
  • Function : Author
Mehdi Touat
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Marc Sanson
Caroline Dehais
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Caroline Houillier
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Florence Laigle-Donadey
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Dimitri Psimaras
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Agusti Alenton
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Nadia Younan
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Nicolas Villain
Maria del Mar Amador
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Nicolas Mezouar
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Graziella Mangone
Aurelie Meneret
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Andreas Hartmann
Clement Tarrano
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David Bendetowicz
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Pierre-François Pradat
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Michel Baulac
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Phintip Pichit
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Florence Chochon
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an Hung Nguyen
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Valerie Porcher
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Alexandre Demoule
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Elise Morawiec
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Julien Mayaux
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Morgan Faure
  • Function : Author
Claire Ewenczyk
Giulia Coarelli
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Anna Heinzmann
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Marion Masingue
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Guillaume Bassez
Isabelle An
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Yulia Worbe
Virginie Lambrecq
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Rabab Debs
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Esteban Munoz Musat
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Timothee Lenglet
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Aurelie Hanin
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Lydia Chougar
Nathalia Shor
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Nadya Pyatigorskaya
Damien Galanaud
Delphine Leclercq
Albert Cao
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Clemence Marois
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Nicolas Weiss
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Loic Le Guennec
Vincent Degos
Alice Jacquens
Thomas Similowski
Capucine Morelot-Panzini
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Jean-Yves Rotge
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Bertrand Saudreau
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Nassim Sarni
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Nathalie Girault
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Smaranda Leu
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Lionel Thivard
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Karima Mokhtari
  • Function : Author
Isabelle Plu
Bruno Gonçalves
Laure Bottin
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Rebecca Haddad
Carmelo Lafuente
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Christel Oasi
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Bruno Megabarne
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Dominique Herve
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Haysam Salman
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Armelle Rametti-Lacroux
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Alize Chalançon
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Anais Herve
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Hugo Royer
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Florence Beauzor
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Valentine Maheo
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Christelle Laganot
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Camille Minelli
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Aurelie Fekete
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Abel Grine
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Marie Biet
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Rania Hilab
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Aurore Besnard
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Meriem Bouguerra
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Gwen Goudard
  • Function : Author
Saida Houairi
  • Function : Author
Saba Al-Youssef
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Christine Pires
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Anissa Oukhedouma
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Katarzyna Siuda-Krzywicka
  • Function : Author
Tal Seidel Malkinson
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Hanane Agguini
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Safia Said
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Ana Zenovia Gales
Vanessa Batista Brochard
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Kiyoka Kinugawa Bourron
  • Function : Author
An Hung Nguyen
  • Function : Author
Esteban Munoz Musat
  • Function : Author
Tal Seidel Malkinson

Abstract

A variety of neuropsychiatric complications has been described in association with COVID-19 infection. Large scale studies presenting a wider picture of these complications and their relative frequency are lacking. The objective of our study was to describe the spectrum of neurological and psychiatric complications in patients with COVID-19 seen in a multidisciplinary hospital centre over 6 months. We conducted a retrospective, observational study of all patients showing neurological or psychiatric symptoms in the context of COVID-19 seen in the medical and university neuroscience department of Assistance Publique Hopitaux de Paris-Sorbonne University. We collected demographic data, comorbidities, symptoms and severity of COVID-19 infection, neurological and psychiatric symptoms, neurological and psychiatric examination data and, when available, results from CSF analysis, MRI, EEG and EMG. A total of 249 COVID-19 patients with a de novo neurological or psychiatric manifestation were included in the database and 245 were included in the final analyses. One-hundred fourteen patients (47%) were admitted to the intensive care unit and 10 (4%) died. The most frequent neuropsychiatric complications diagnosed were encephalopathy (43%), critical illness polyneuropathy and myopathy (26%), isolated psychiatric disturbance (18%) and cerebrovascular disorders (16%). No patients showed CSF evidence of SARS-CoV-2. Encephalopathy was associated with older age and higher risk of death. Critical illness neuromyopathy was associated with an extended stay in the intensive care unit. The majority of these neuropsychiatric complications could be imputed to critical illness, intensive care and systemic inflammation, which contrasts with the paucity of more direct SARS-CoV-2-related complications or post-infection disorders.
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Dates and versions

hal-03464402 , version 1 (03-12-2021)

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Cécile Delorme, Marion Houot, Charlotte Rosso, Stéphanie Carvalho, Thomas Nedelec, et al.. The wide spectrum of COVID-19 neuropsychiatric complications within a multidisciplinary centre. Brain Communications, 2021, 3 (3), ⟨10.1093/braincomms/fcab135⟩. ⟨hal-03464402⟩
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