The wide spectrum of COVID-19 neuropsychiatric complications within a multidisciplinary centre
Cécile Delorme
(1)
,
Marion Houot
(2)
,
Charlotte Rosso
(1)
,
Stéphanie Carvalho
(1)
,
Thomas Nedelec
(1)
,
Redwan Maatoug
(2)
,
Victor Pitron
(2)
,
Salimata Gassama
(2)
,
Sara Sambin
(2)
,
Stéphanie Bombois
(2)
,
Bastien Herlin
(2)
,
Gaëlle Ouvrard
(3)
,
Gaëlle Bruneteau
(4, 2)
,
Adèle Hesters
(2)
,
Ana Zenovia Gales
(2)
,
Bruno Millet
(2, 1)
,
Foudil Lamari
(2)
,
Stéphane Lehericy
(1, 2)
,
Vincent Navarro
(1, 2)
,
Benjamin Rohaut
(1, 2)
,
Sophie Demeret
(2)
,
Thierry Maisonobe
(2, 2)
,
Marion Yger
(5)
,
Bertrand Degos
(2)
,
Louise-Laure Mariani
(2, 1)
,
Christophe Bouche
(2)
,
Nathalie Dzierzynski
(6)
,
Bruno Oquendo
(2)
,
Flora Ketz
(2)
,
An-Hung Nguyen
(2)
,
Aurélie Kas
(2)
,
Catherine Lubetzki
(2, 1)
,
Jean-Yves Delattre
(1)
,
Jean-Christophe Corvol
(1, 2)
,
Bertrand Fontaine
(1)
,
Philippe Thoumie
,
Tarek Sharshar
,
Sonia Alamowitch
,
Emmanuelle Apartis-Bourdieu
,
Charles-Siegried Peretti
,
Renata Ursu
,
Kiyoka Kinugawa Bourron
,
Joel Belmin
,
Eric Pautas
,
Marc Verny
,
Yves Samson
,
Sara Leder
,
Anne Leger
,
Sandrine Deltour
,
Flore Baronnet
,
Mehdi Touat
,
Marc Sanson
,
Caroline Dehais
,
Caroline Houillier
,
Florence Laigle-Donadey
,
Dimitri Psimaras
,
Agusti Alenton
,
Nadia Younan
,
Nicolas Villain
,
Maria del Mar Amador
,
Nicolas Mezouar
,
Graziella Mangone
,
Aurelie Meneret
,
Andreas Hartmann
,
Clement Tarrano
,
David Bendetowicz
,
Pierre-François Pradat
,
Michel Baulac
,
Phintip Pichit
,
Florence Chochon
,
an Hung Nguyen
,
Valerie Porcher
,
Alexandre Demoule
,
Elise Morawiec
,
Julien Mayaux
,
Morgan Faure
,
Claire Ewenczyk
,
Giulia Coarelli
,
Anna Heinzmann
,
Marion Masingue
,
Guillaume Bassez
,
Isabelle An
,
Yulia Worbe
,
Virginie Lambrecq
,
Rabab Debs
,
Esteban Munoz Musat
,
Timothee Lenglet
,
Aurelie Hanin
,
Lydia Chougar
,
Nathalia Shor
,
Nadya Pyatigorskaya
,
Damien Galanaud
,
Delphine Leclercq
,
Albert Cao
,
Clemence Marois
,
Nicolas Weiss
,
Loic Le Guennec
,
Vincent Degos
,
Alice Jacquens
,
Thomas Similowski
,
Capucine Morelot-Panzini
,
Jean-Yves Rotge
,
Bertrand Saudreau
,
Nassim Sarni
,
Nathalie Girault
,
Smaranda Leu
,
Lionel Thivard
,
Karima Mokhtari
,
Isabelle Plu
,
Bruno Gonçalves
,
Laure Bottin
,
Rebecca Haddad
,
Carmelo Lafuente
,
Christel Oasi
,
Bruno Megabarne
,
Dominique Herve
,
Haysam Salman
,
Armelle Rametti-Lacroux
,
Alize Chalançon
,
Anais Herve
,
Hugo Royer
,
Florence Beauzor
,
Valentine Maheo
,
Christelle Laganot
,
Camille Minelli
,
Aurelie Fekete
,
Abel Grine
,
Marie Biet
,
Rania Hilab
,
Aurore Besnard
,
Meriem Bouguerra
,
Gwen Goudard
,
Saida Houairi
,
Saba Al-Youssef
,
Christine Pires
,
Anissa Oukhedouma
,
Katarzyna Siuda-Krzywicka
,
Tal Seidel Malkinson
,
Hanane Agguini
,
Safia Said
,
Ana Zenovia Gales
,
Vanessa Batista Brochard
,
Kiyoka Kinugawa Bourron
,
An Hung Nguyen
,
Esteban Munoz Musat
,
Tal Seidel Malkinson
Cécile Delorme
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Thomas Nedelec
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Sara Sambin
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Bastien Herlin
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Ana Zenovia Gales
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Foudil Lamari
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Stéphane Lehericy
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Vincent Navarro
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Benjamin Rohaut
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Louise-Laure Mariani
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Jean-Christophe Corvol
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Bertrand Fontaine
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Philippe Thoumie
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Tarek Sharshar
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Sonia Alamowitch
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Emmanuelle Apartis-Bourdieu
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Charles-Siegried Peretti
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Renata Ursu
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Kiyoka Kinugawa Bourron
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Joel Belmin
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Eric Pautas
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Marc Verny
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Yves Samson
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Sara Leder
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Anne Leger
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Sandrine Deltour
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Flore Baronnet
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Mehdi Touat
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Marc Sanson
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Caroline Dehais
- Function : Author
Caroline Houillier
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Florence Laigle-Donadey
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Dimitri Psimaras
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Agusti Alenton
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Nadia Younan
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Nicolas Villain
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Maria del Mar Amador
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Nicolas Mezouar
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Graziella Mangone
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Aurelie Meneret
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Andreas Hartmann
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Clement Tarrano
- Function : Author
David Bendetowicz
- Function : Author
Pierre-François Pradat
- Function : Author
Michel Baulac
- Function : Author
Phintip Pichit
- Function : Author
Florence Chochon
- Function : Author
an Hung Nguyen
- Function : Author
Valerie Porcher
- Function : Author
Alexandre Demoule
- Function : Author
Elise Morawiec
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Julien Mayaux
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Morgan Faure
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Claire Ewenczyk
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Giulia Coarelli
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Anna Heinzmann
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Marion Masingue
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Guillaume Bassez
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Isabelle An
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Yulia Worbe
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Virginie Lambrecq
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Rabab Debs
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Esteban Munoz Musat
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Timothee Lenglet
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Aurelie Hanin
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Lydia Chougar
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Nathalia Shor
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Nadya Pyatigorskaya
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Damien Galanaud
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Delphine Leclercq
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Albert Cao
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Clemence Marois
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Nicolas Weiss
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Loic Le Guennec
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Vincent Degos
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Alice Jacquens
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Thomas Similowski
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Capucine Morelot-Panzini
- Function : Author
Jean-Yves Rotge
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Bertrand Saudreau
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Nassim Sarni
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Nathalie Girault
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Smaranda Leu
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Lionel Thivard
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Karima Mokhtari
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Isabelle Plu
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Bruno Gonçalves
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Laure Bottin
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Rebecca Haddad
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Carmelo Lafuente
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Christel Oasi
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Bruno Megabarne
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Dominique Herve
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Haysam Salman
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Armelle Rametti-Lacroux
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Alize Chalançon
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Anais Herve
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Hugo Royer
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Florence Beauzor
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Valentine Maheo
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Christelle Laganot
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Camille Minelli
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Aurelie Fekete
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Abel Grine
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Marie Biet
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Rania Hilab
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Aurore Besnard
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Meriem Bouguerra
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Gwen Goudard
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Saida Houairi
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Saba Al-Youssef
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Christine Pires
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Anissa Oukhedouma
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Katarzyna Siuda-Krzywicka
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Tal Seidel Malkinson
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Hanane Agguini
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Safia Said
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Ana Zenovia Gales
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Vanessa Batista Brochard
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Kiyoka Kinugawa Bourron
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An Hung Nguyen
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Esteban Munoz Musat
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Tal Seidel Malkinson
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Abstract
A variety of neuropsychiatric complications has been described in association with COVID-19 infection. Large scale studies presenting a wider picture of these complications and their relative frequency are lacking. The objective of our study was to describe the spectrum of neurological and psychiatric complications in patients with COVID-19 seen in a multidisciplinary hospital centre over 6 months. We conducted a retrospective, observational study of all patients showing neurological or psychiatric symptoms in the context of COVID-19 seen in the medical and university neuroscience department of Assistance Publique Hopitaux de Paris-Sorbonne University. We collected demographic data, comorbidities, symptoms and severity of COVID-19 infection, neurological and psychiatric symptoms, neurological and psychiatric examination data and, when available, results from CSF analysis, MRI, EEG and EMG. A total of 249 COVID-19 patients with a de novo neurological or psychiatric manifestation were included in the database and 245 were included in the final analyses. One-hundred fourteen patients (47%) were admitted to the intensive care unit and 10 (4%) died. The most frequent neuropsychiatric complications diagnosed were encephalopathy (43%), critical illness polyneuropathy and myopathy (26%), isolated psychiatric disturbance (18%) and cerebrovascular disorders (16%). No patients showed CSF evidence of SARS-CoV-2. Encephalopathy was associated with older age and higher risk of death. Critical illness neuromyopathy was associated with an extended stay in the intensive care unit. The majority of these neuropsychiatric complications could be imputed to critical illness, intensive care and systemic inflammation, which contrasts with the paucity of more direct SARS-CoV-2-related complications or post-infection disorders.
Origin | Publication funded by an institution |
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