How to Intensify Treatment in Older Patients With Hypertension: Is There a Single Answer? - Sorbonne Université
Article Dans Une Revue Annals of Internal Medicine Année : 2021

How to Intensify Treatment in Older Patients With Hypertension: Is There a Single Answer?

Olivier Steichen

Résumé

Randomized trials show that half-dose dual combination therapies for hypertension reduce blood pressure (BP) more than full-dose monotherapies, with no more adverse effects (1). Indeed, combining 2 drugs has an additive effect on BP reduction, whereas increasing the dose of a drug is less than additive (2): A half dose is only 25% less potent than a full dose. Under these assumptions, the expected potency of antihypertensive drug combinations can be approximated (Table). For example, the combination of 2 drugs at half dose is expected to be 50% more potent than a single drug at full dose. Using half doses ...
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Dates et versions

hal-03520577 , version 1 (11-01-2022)

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Olivier Steichen. How to Intensify Treatment in Older Patients With Hypertension: Is There a Single Answer?. Annals of Internal Medicine, 2021, 174 (12), pp.1749-1750. ⟨10.7326/M21-3648⟩. ⟨hal-03520577⟩
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