Ureasil-polyether-CoFe 2 O 4 nanocomposites: Coupling drug delivery system and magnetic hyperthermia - Sorbonne Université
Article Dans Une Revue ACS Applied Polymer Materials Année : 2021

Ureasil-polyether-CoFe 2 O 4 nanocomposites: Coupling drug delivery system and magnetic hyperthermia

Résumé

In this work, we evaluate the effect of the ureasil–polyether hybrid nature on the magnetic hyperthermia (MH) properties and drug delivery patterns of nanocomposites prepared by the conjugation of cobalt ferrite (CoFe2O4) superparamagnetic nanoparticles (SPN) with ureasil–poly(propylene oxide) (UPPO) and ureasil–poly(ethylene oxide) (UPEO). The results of small-angle X-ray scattering (SAXS) and differential scanning calorimetry (DSC) analyses evidenced that the nanoscopic structure and thermal properties remained essentially unaffected by conjugation of the SPN with the hybrid material. The lower heat capacity of the UPPO–CoFe2O4 nanocomposite promoted a higher efficiency of MH compared to the UPEO–CoFe2O4 nanocomposite. The temperature variations achieved by UPPO–CoFe2O4 and UPEO–CoFe2O4 were 34 and 20 °C, respectively, when subjected to an alternating magnetic field (AMF) for 240 s. The drug delivery patterns of sodium diclofenac (SDCF) from UPPO and UPEO were unaffected by the conjugation with SPN or by MH.
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Dates et versions

hal-03525734 , version 1 (14-01-2022)

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Citer

Willian Max O. S. de Santana, Sébastien Abramson, Rodolfo Fini, Bruno L Caetano, Christine Ménager, et al.. Ureasil-polyether-CoFe 2 O 4 nanocomposites: Coupling drug delivery system and magnetic hyperthermia. ACS Applied Polymer Materials, 2021, 3 (10), pp.4837-4848. ⟨10.1021/acsapm.1c00496⟩. ⟨hal-03525734⟩
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