The “Immunoscore” in rectal cancer: could we search quality beyond quantity of life? - Sorbonne Université
Journal Articles Oncotarget Year : 2022

The “Immunoscore” in rectal cancer: could we search quality beyond quantity of life?

Angelita Habr-Gama
  • Function : Author
Rodrigo Perez
  • Function : Author

Abstract

Because of the function and anatomical environment of the rectum, therapeutic strategies for local advanced rectal cancer (LARC) must deal with two challenging stressors that are a high-risk of local and distal recurrences and a high-risk of poor quality of life (QoL). Over the last three decades, advances in screening tests, therapies, and combined-modality treatment options and strategies have improved the prognosis of patients with LARC. However, owing to the heterogeneous nature of LARC and genetic status, the patient may not respond to a specific therapy and may be at increased risk of side-effects without the life-prolonging benefit. Indeed, each therapy can cause its own side-effects, which may worsen by a combination of treatments resulting in long-term poor QoL. In LARC, QoL has become even more essential with the increasing incidence of rectal cancer in young individuals. Herein, we analyzed the value of the Immunoscore-Biopsy (performed on tumor biopsy at diagnosis) in predicting outcomes, alone or in association with clinical and imaging data, for each therapy used in LARC.

Domains

Cancer
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Origin Publication funded by an institution

Dates and versions

hal-03534276 , version 1 (19-01-2022)

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Amos Kirilovsky, Carine El Sissy, Guy Zeitoun, Florence Marliot, Nacilla Haicheur, et al.. The “Immunoscore” in rectal cancer: could we search quality beyond quantity of life?. Oncotarget, 2022, 13 (1), pp.18-31. ⟨10.18632/oncotarget.28100⟩. ⟨hal-03534276⟩
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