“Double-Hit” Chronic Lymphocytic Leukemia, Involving the TP53 and MYC Genes - Sorbonne Université
Journal Articles Frontiers in Oncology Year : 2022

“Double-Hit” Chronic Lymphocytic Leukemia, Involving the TP53 and MYC Genes

Abstract

Although the 17p deletion [del(17p)] is rare in cases of treatment-naive chronic lymphocytic leukemia (CLL), its frequency is higher in refractory/relapsed CLLparticularly in patients undergoing chemo(immuno)therapy. TP53 disruption (deletion and/or mutation) is the strongest prognostic factor for refractoriness to chemotherapy; the use of Bruton tyrosine kinase inhibitors and BCL2 inhibitors is then indicated. Rare cases of CLL can also harbor translocation or gain of the MYC oncogene. "Double-hit CLL" (with del(17p) and MYC gain) is associated with a very poor prognosis. The prognostic impact of TP53 disruption with MYC aberrations in patients receiving targeted therapies must now be evaluated.

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Cancer
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Dates and versions

hal-03551259 , version 1 (01-02-2022)

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Florence Nguyen-Khac. “Double-Hit” Chronic Lymphocytic Leukemia, Involving the TP53 and MYC Genes. Frontiers in Oncology, 2022, 11, ⟨10.3389/fonc.2021.826245⟩. ⟨hal-03551259⟩
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