Dopamine denervation in the functional territories of the striatum: a new MR and atlas-based 123I-FP-CIT SPECT quantification method

Current quantification methods of 123I-FP-CIT SPECT rely on anatomical parcellation of the striatum. We propose here to implement a new method based on MRI segmentation and functional atlas of the basal ganglia (MR-ATLAS) that could provide a reliable quantification within the sensorimotor, associative, and limbic territories of the striatum. Patients with Parkinson’s disease (PD), idiopathic rapid eye movement sleep behavioral disorder (iRBD), and healthy controls underwent 123I-FP-CIT SPECT, MRI, motor, and cognitive assessments. SPECT data were corrected for partial volume effects and registered to a functional atlas of the striatum to allow quantification in every functional region of the striatum (nucleus accumbens, limbic, associative, and sensorimotor parts of the striatum). The MR-ATLAS quantification method is proved to be reliable in every territory of the striatum. In addition, good correlations were found between cognitive dysexecutive tests and the binding within the functional (limbic) territories of the striatum using the MR-ATLAS method, slightly better than correlations found using the anatomical quantification method. This new MR-ATLAS method provides a robust and useful tool for studying the dopaminergic system in PD, particularly with respect to cognitive functions. It may also be relevant to further unravel the relationship between dopaminergic denervation and cognitive or behavioral symptoms.

Keywords

Parkinson's disease 123 I-FP-CIT SPECT idiopathic rapid eye movement sleep behavioral disorder striatum Parkinson's disease

Domains

Neurons and Cognition [q-bio.NC] Human health and pathology Imaging

Fichier principal

Villain_Manuscript_R2.pdf (580.44 Ko)

Figure1 (1).tif (8.22 Mo)

Figure2 (1).tif (2.74 Mo)

Figure3 (1).tif (1.18 Mo)

Figure4 (1).tif (3.16 Mo)

Figure5 (1).tif (1.39 Mo)

Figure6 (1).tif (769.3 Ko)

SupplFigure3 (1).tif (1.77 Mo)

SupplFigure4 (1).tif (2.72 Mo)

SupplFigure5.tif (2.24 Mo)

SupplFigure6 (1).tif (2.05 Mo)

SupplFigure7.tif (1.98 Mo)

Suppl_Figure1 (1).tif (6.94 Mo)

Suppl_Figure2 (1).tif (3.46 Mo)

Origin	Files produced by the author(s)

Nicolas VILLAIN : Connect in order to contact the contributor

https://hal.sorbonne-universite.fr/hal-03668195

Submitted on : Saturday, May 14, 2022-11:59:49 AM

Last modification on : Thursday, November 28, 2024-5:57:36 PM

Dates and versions

hal-03668195 , version 1 (14-05-2022)

Identifiers

HAL Id : hal-03668195 , version 1
DOI : 10.1007/s00702-021-02434-9
PUBMED : 34704162

Cite

Nicolas Villain, G. Béra, Marie-Odile Habert, A. Kas, J. Aubert, et al.. Dopamine denervation in the functional territories of the striatum: a new MR and atlas-based 123I-FP-CIT SPECT quantification method. Journal of Neural Transmission, 2021, 128 (12), pp.1841-1852. ⟨10.1007/s00702-021-02434-9⟩. ⟨hal-03668195⟩

Export

BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite

Collections

INSERM CNRS LIB ICM SORBONNE-UNIVERSITE SU-MEDECINE SU-SCIENCES ANR

94 View

163 Download