Immunity against Influenza A(H1N1) Infections Is Determined by Age at the Time of Initial Strain Circulation - Sorbonne Université Access content directly
Journal Articles Epidemiology and Infection Year : 2017

Immunity against Influenza A(H1N1) Infections Is Determined by Age at the Time of Initial Strain Circulation

Abstract

We explored age-dependent patterns in haemagglutination inhibition (HI) titre to seasonal [1956 A(H1N1), 1977 A(H1N1), 2007 A(H1N1)] and pandemic [A(H1N1)pdm09] influenza strains using serological data collected from an adult French influenza cohort. Subjects were recruited by their general practitioners from 2008 to 2009 and followed until 2010. We explored age-related differences between strain-specific HI titres using 1053 serological samples collected over the study period from 398 unvaccinated subjects. HI titres against the tested seasonal and pandemic strains were determined using the HI technique. Geometric mean titres (GMTs) were estimated using regression models for interval-censored data. Generalized additive mixed models were fit to log-transformed HI estimates to study the relationship between HI titre and age (age at inclusion and/or age at initial strain circulation). GMT against one strain was consistently highest in the birth cohort exposed to that strain during childhood, with peak titres observed in subjects aged 7-8 years at the time of initial strain circulation. Our results complete previous findings on influenza A(H3N2) strains and identify a strain-dependent relationship between HI titre and age at initial strain circulation.
Fichier principal
Vignette du fichier
immunity_influenza.pdf (234.68 Ko) Télécharger le fichier
Origin Publisher files allowed on an open archive

Dates and versions

hal-03703928 , version 1 (06-10-2022)

Identifiers

Cite

R. M. Delabre, N. Salez, N. Lapidus, M. Lemaitre, M. Leruez-Ville, et al.. Immunity against Influenza A(H1N1) Infections Is Determined by Age at the Time of Initial Strain Circulation. Epidemiology and Infection, 2017, 145 (1), pp.141--147. ⟨10.1017/S0950268816002156⟩. ⟨hal-03703928⟩
75 View
19 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More