Antiretroviral Drug Reduction in Highly Experienced HIV-infected Patients Receiving a Multidrug Regimen: The ECOVIR Study - Sorbonne Université
Journal Articles Journal of Antimicrobial Chemotherapy Year : 2019

Antiretroviral Drug Reduction in Highly Experienced HIV-infected Patients Receiving a Multidrug Regimen: The ECOVIR Study

Abstract

Abstract Objectives In a context of life-long therapy, we asked whether it could be possible to reduce the number of antiretroviral drugs without jeopardizing viral suppression. Methods ECOVIR was a prospective study aiming to assess whether in patients on combination ART with ≥q4 antiretrovirals for ≥q24\,weeks and virally suppressed for ≥q48\,weeks, a drug-reduced (DR) regimen could be proposed. The intervention consisted of discontinuing genotypically less susceptible drugs to reach a DR regimen with ≤q3 antiretrovirals. The primary endpoint was the proportion of patients maintaining viral suppression at week (W) 24. Results From 89 eligible individuals for the study, a DR regimen was proposed in 86 (97%) patients, of whom 71 were switched to a DR regimen. Baseline characteristics [median (IQR)] were: age 58 (53\textendash 65) years, duration of treatment 24 (21\textendash 26) years and viral suppression 8 (6\textendash 11) years. The cumulative resistance profile showed full resistance to lamivudine/emtricitabine (91%), abacavir (74%), efavirenz/nevirapine (70%), rilpivirine (56%), darunavir (q24h/q12h) (42%/29%), lopinavir (69%), atazanavir (71%) and raltegravir (24%). The final DR regimen consisted of a two-drug or three-drug regimen in 54 patients (76%) and in 17 patients (24%), respectively. The success rate of a DR regimen at W24 was 93.9% (95% CI 84.4\textendash 97.6, Kaplan\textendash Meier estimate). Four patients experienced virological failure (at W4, W8 and W12), all with plasma viral load (pVL) <600 copies/mL and no emergence of resistance mutations. The DR strategy allowed a monthly cost saving of 36%. Conclusions In experienced patients with high-level resistance, individualized strategies based on expert advice can offer DR regimen options with fewer drug\textendash drug interactions and a significant economic impact while ensuring virological success.
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Dates and versions

hal-03704034 , version 1 (24-06-2022)

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Marc-Antoine Valantin, Lise Durand, Marc Wirden, Lambert Assoumou, Fabienne Caby, et al.. Antiretroviral Drug Reduction in Highly Experienced HIV-infected Patients Receiving a Multidrug Regimen: The ECOVIR Study. Journal of Antimicrobial Chemotherapy, 2019, 74 (9), pp.2716--2722. ⟨10.1093/jac/dkz255⟩. ⟨hal-03704034⟩
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