Influence of Hepatitis C Coinfection and Treatment on Risk of Diabetes Mellitus in HIV-Positive Persons - Sorbonne Université
Journal Articles Open Forum Infectious Diseases Year : 2020

Influence of Hepatitis C Coinfection and Treatment on Risk of Diabetes Mellitus in HIV-Positive Persons

Amanda Mocroft (1) , Jens D Lundgren (2) , Juergen K Rockstroh (3) , Inka Aho (4) , Gilles Wandeler (5) , Lars Nielsen (6) , Simon Edwards (7) , Jean-Paul Viard (8) , Karine Lacombe (9) , Gerd Fatkenheuer (10) , Giovanni Guaraldi (11) , Montserrat Laguno (12) , Josep Llibre (13) , Hila Elinav (14) , Leo Flamholc (15) , Martin Gisinger (16) , Dzmitry Paduta , Irina Khromova , David Jilich (17) , Blazej Rozplochowski (18) , Cristiana Oprea (19) , Lars Peters (1) , A Harxhi , M Losso , M Kundro , B Schmied , R Zangerle (16) , I Karpov , A Vassilenko , D Paduto , N Clumeck , S de Wit , M Delforge , E Florence , L Vandekerckhove , V Hadziosmanovic , J Begovac , L Machala , D Jilich , D Sedlacek , G Kronborg , T Benfield , J Gerstoft , T Katzenstein , C Pedersen , I S Johansen , L Ostergaard , L Wiese , N F Moller , K Zilmer , I Aho , J-P Viard (8) , P-M Girard (20) , C Pradier (21) , E Fontas , C Duvivier (22) , J Rockstroh (3) , G Behrens (23) , O Degen , H J Stellbrink , J Bogner , G Fätkenheuer (24) , N Chkhartishvili , H Sambatakou , G Adamis , N Paissios , J Szlávik , M Gottfredsson , C Kelly , L Tau , D Turner , M Burke , E Shahar , G Hassoun , H Elinav , M Haouzi , D Elbirt , A d'Arminio Monforte , R Esposito , I Mazeu , C Mussini (11, 25) , F Mazzotta , A Gabbuti , A Lazzarin , A Castagna (26) , N Gianotti , M Galli , A Ridolfo , V Uzdaviniene , R Matulionyte , T Staub , R Hemmer , S Dragas , M Stevanovic , P Reiss , J Trajanovska , D H Reikvam , A Maeland , J Bruun , B Knysz , J Gasiorowski , M Inglot , E Bakowska , R Flisiak , A Grzeszczuk , M Parczewski , K Maciejewska , B Aksak-Was , M Beniowski , E Mularska , E Jablonowska , J Kamerys , K Wojcik , I Mozer-Lisewska , B Rozplochowski , A Zagalo , K Mansinho , F Maltez , C Oprea , A Yakovlev , I Khromova , E Kuzovatova , E Borodulina , E Vdoushkina , J Ranin , J Tomazic , J M Miro , M Laguno , E Martínez , F Garcia , J L Blanco , M Martinez-Rebollar , J Mallolas , P Callau , J Rojas , A Inciarta , S Moreno (27) , B Clotet , A Jou , R Paredes , J Puig , J M Llibre , J R Santos , P Domingo , M Gutierrez , G Mateo , M A Sambeat , J M Laporte , K Falconer , A Thalme , A Sonnerborg , C J Treutiger , L Flamholc , A Scherrer , R Weber , M Cavassini , A Calmy , H Furrer , M Battegay (28) , P Schmid , A Kuznetsova , J Mikhalik , M Sluzhynska , A Milinkovic , a M Johnson , E Simons , S Edwards , A Phillips , M A Johnson , A Mocroft , A Winston (29) , A Clarke , C Leen , I Karpov , M Losso , J Lundgren , J Rockstroh (3) , I Aho , L D Rasmussen , V Svedhem , G Wandeler , C Pradier (21) , N Chkhartishvili , R Matulionyte , C Oprea , J D Kowalska , J Begovac , J M Miró , G Guaraldi (11) , R Paredes , G Wandeler , R Paredes , O Kirk , L Peters , A Bojesen , D Raben , E V Hansen , D Kristensen , J F Larsen , a H Fischer , A Mocroft (1) , A Phillips , A Cozzi-Lepri , S Amele , A Pelchen-Matthews , A Roen
1 UCL - University College of London [London]
2 Rigshospitalet [Copenhagen]
3 University Hospital Bonn
4 HUS - Helsinki University Hospital [Finland]
5 Inselspital - Bern University Hospital [Berne]
6 Nordsjællands Hospital [Hillerød, Denmark]
7 Mortimer Market Centre
8 Hôpital Hôtel-Dieu [Paris]
9 iPLESP - Institut Pierre Louis d'Epidémiologie et de Santé Publique
10 University Hospital of Cologne [Cologne]
11 UNIMORE - Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia
12 Clinic Barcelona Hospital Universitari
13 GTPUH - Germans Trias i Pujol University Hospital [Badalona, Barcelona, Spain]
14 Hadassah Hebrew University Medical Center [Jerusalem]
15 Skane University Hospital [Malmo]
16 IMU - Innsbruck Medical University = Medizinische Universität Innsbruck
17 UK - Univerzita Karlova [Praha, Česká republika] = Charles University [Prague, Czech Republic]
18 PUMS - Poznan University of Medical Sciences [Poland]
19 UMPCD - University of Medicine and Pharmacy “Carol Davila”
20 CHU Saint-Antoine [AP-HP]
21 CHU - Hôpital Archet 2 [Nice]
22 Hôpital Necker - Enfants Malades [AP-HP]
23 MHH - Medizinische Hochschule Hannover = Hannover Medical School
24 Universität zu Köln = University of Cologne
25 Azienda Ospedaleria Universitaria di Modena = University Hospital of Modena
26 UniSR - Universita Vita Salute San Raffaele = Vita-Salute San Raffaele University [Milan, Italie]
27 Hospital Universitario Ramón y Cajal [Madrid]
28 University Hospital Basel [Basel]
29 Imperial College London
Dzmitry Paduta
  • Function : Author
Irina Khromova
  • Function : Author
A Harxhi
  • Function : Author
M Losso
  • Function : Author
M Kundro
  • Function : Author
B Schmied
  • Function : Author
I Karpov
  • Function : Author
A Vassilenko
  • Function : Author
D Paduto
  • Function : Author
N Clumeck
  • Function : Author
S de Wit
  • Function : Author
M Delforge
  • Function : Author
E Florence
  • Function : Author
L Vandekerckhove
  • Function : Author
V Hadziosmanovic
  • Function : Author
J Begovac
  • Function : Author
L Machala
  • Function : Author
D Jilich
  • Function : Author
D Sedlacek
  • Function : Author
G Kronborg
  • Function : Author
T Benfield
  • Function : Author
J Gerstoft
  • Function : Author
T Katzenstein
  • Function : Author
C Pedersen
  • Function : Author
I S Johansen
  • Function : Author
L Ostergaard
  • Function : Author
L Wiese
  • Function : Author
N F Moller
  • Function : Author
K Zilmer
  • Function : Author
I Aho
  • Function : Author
E Fontas
  • Function : Author
O Degen
  • Function : Author
H J Stellbrink
  • Function : Author
J Bogner
  • Function : Author
N Chkhartishvili
  • Function : Author
H Sambatakou
  • Function : Author
G Adamis
  • Function : Author
N Paissios
  • Function : Author
J Szlávik
  • Function : Author
M Gottfredsson
  • Function : Author
C Kelly
  • Function : Author
L Tau
  • Function : Author
D Turner
  • Function : Author
M Burke
  • Function : Author
E Shahar
  • Function : Author
G Hassoun
  • Function : Author
H Elinav
  • Function : Author
M Haouzi
  • Function : Author
D Elbirt
  • Function : Author
A d'Arminio Monforte
  • Function : Author
R Esposito
  • Function : Author
I Mazeu
  • Function : Author
F Mazzotta
  • Function : Author
A Gabbuti
  • Function : Author
A Lazzarin
  • Function : Author
N Gianotti
  • Function : Author
M Galli
  • Function : Author
A Ridolfo
  • Function : Author
V Uzdaviniene
  • Function : Author
R Matulionyte
  • Function : Author
T Staub
  • Function : Author
R Hemmer
  • Function : Author
S Dragas
  • Function : Author
M Stevanovic
  • Function : Author
P Reiss
  • Function : Author
J Trajanovska
  • Function : Author
D H Reikvam
  • Function : Author
A Maeland
  • Function : Author
J Bruun
  • Function : Author
B Knysz
  • Function : Author
J Gasiorowski
  • Function : Author
M Inglot
  • Function : Author
E Bakowska
  • Function : Author
R Flisiak
  • Function : Author
A Grzeszczuk
  • Function : Author
M Parczewski
  • Function : Author
K Maciejewska
  • Function : Author
B Aksak-Was
  • Function : Author
M Beniowski
  • Function : Author
E Mularska
  • Function : Author
E Jablonowska
  • Function : Author
J Kamerys
  • Function : Author
K Wojcik
  • Function : Author
I Mozer-Lisewska
  • Function : Author
B Rozplochowski
  • Function : Author
A Zagalo
  • Function : Author
K Mansinho
  • Function : Author
F Maltez
  • Function : Author
C Oprea
  • Function : Author
A Yakovlev
  • Function : Author
I Khromova
  • Function : Author
E Kuzovatova
  • Function : Author
E Borodulina
  • Function : Author
E Vdoushkina
  • Function : Author
J Ranin
  • Function : Author
J Tomazic
  • Function : Author
J M Miro
  • Function : Author
M Laguno
  • Function : Author
E Martínez
  • Function : Author
F Garcia
  • Function : Author
J L Blanco
  • Function : Author
M Martinez-Rebollar
  • Function : Author
J Mallolas
  • Function : Author
P Callau
  • Function : Author
J Rojas
  • Function : Author
A Inciarta
  • Function : Author
B Clotet
  • Function : Author
A Jou
  • Function : Author
R Paredes
  • Function : Author
J Puig
  • Function : Author
J M Llibre
  • Function : Author
J R Santos
  • Function : Author
P Domingo
  • Function : Author
M Gutierrez
  • Function : Author
G Mateo
  • Function : Author
M A Sambeat
  • Function : Author
J M Laporte
  • Function : Author
K Falconer
  • Function : Author
A Thalme
  • Function : Author
A Sonnerborg
  • Function : Author
C J Treutiger
  • Function : Author
L Flamholc
  • Function : Author
A Scherrer
  • Function : Author
R Weber
  • Function : Author
M Cavassini
  • Function : Author
A Calmy
  • Function : Author
H Furrer
  • Function : Author
P Schmid
  • Function : Author
A Kuznetsova
  • Function : Author
J Mikhalik
  • Function : Author
M Sluzhynska
  • Function : Author
A Milinkovic
  • Function : Author
a M Johnson
  • Function : Author
E Simons
  • Function : Author
S Edwards
  • Function : Author
A Phillips
  • Function : Author
M A Johnson
  • Function : Author
A Mocroft
  • Function : Author
A Clarke
  • Function : Author
C Leen
  • Function : Author
I Karpov
  • Function : Author
M Losso
  • Function : Author
J Lundgren
  • Function : Author
I Aho
  • Function : Author
L D Rasmussen
  • Function : Author
V Svedhem
  • Function : Author
G Wandeler
  • Function : Author
N Chkhartishvili
  • Function : Author
R Matulionyte
  • Function : Author
C Oprea
  • Function : Author
J D Kowalska
  • Function : Author
J Begovac
  • Function : Author
J M Miró
  • Function : Author
R Paredes
  • Function : Author
G Wandeler
  • Function : Author
R Paredes
  • Function : Author
O Kirk
  • Function : Author
L Peters
  • Function : Author
A Bojesen
  • Function : Author
D Raben
  • Function : Author
E V Hansen
  • Function : Author
D Kristensen
  • Function : Author
J F Larsen
  • Function : Author
a H Fischer
  • Function : Author
A Phillips
  • Function : Author
A Cozzi-Lepri
  • Function : Author
S Amele
  • Function : Author
A Pelchen-Matthews
  • Function : Author
A Roen
  • Function : Author

Abstract

Abstract Background The role of hepatitis C virus (HCV) coinfection and HCV-RNA in the development of diabetes mellitus (DM) in HIV-positive persons remains unclear. Methods Poisson regression was used to compare incidence rates of DM (blood glucose\hspace0.25em>11.1 mmol/L, HbA1C >6.5% or >48 mmol/mol, starting antidiabetic medicine or physician reported date of DM onset) between current HIV/HCV groups (anti-HCV-negative, spontaneously cleared HCV, chronic untreated HCV, successfully treated HCV, HCV-RNA-positive after HCV treatment). Results A total of 16 099 persons were included; at baseline 10 091 (62.7%) were HCV-Ab-negative, 722 (4.5%) were spontaneous clearers, 3614 (22.4%) were chronically infected, 912 (5.7%) had been successfully treated, and 760 (4.7%) were HCV-RNA-positive after treatment. During 136 084 person-years of follow-up (PYFU; median [interquartile range], 6.9 [3.6\textendash 13.2]), 1108 (6.9%) developed DM (crude incidence rate, 8.1/1000 PYFU; 95% CI, 7.7\textendash 8.6). After adjustment, there was no difference between the 5 HCV strata in incidence of DM (global P\hspace0.25em=\hspace0.25em.33). Hypertension (22.2%; 95% CI, 17.5%\textendash 26.2%) and body mass index\hspace0.25em>25 (22.0%; 95% CI, 10.4%\textendash 29.7%) had the largest population-attributable fractions for DM. Conclusions HCV coinfection and HCV cure were not associated with DM in this large study. The biggest modifiable risk factors were hypertension and obesity, and continued efforts to manage such comorbidities should be prioritized.

Dates and versions

hal-03707487 , version 1 (28-06-2022)

Identifiers

Cite

Amanda Mocroft, Jens D Lundgren, Juergen K Rockstroh, Inka Aho, Gilles Wandeler, et al.. Influence of Hepatitis C Coinfection and Treatment on Risk of Diabetes Mellitus in HIV-Positive Persons. Open Forum Infectious Diseases, 2020, 7 (12), pp.ofaa470. ⟨10.1093/ofid/ofaa470⟩. ⟨hal-03707487⟩
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