Switching from boosted PIs to dolutegravir decreases soluble CD14 and adiponectin in high cardiovascular risk people living with HIV

Ana González-Cordón; Lambert Assoumou; Graeme Moyle; Laura Waters; Margaret Johnson; Pere Domingo; Julie Fox; Hans-Jürgen Stellbrink; Giovanni Guaraldi; Mar Masiá; Mark Gompels; Stephane de Wit; Eric Florence; Stefan Esser; François Raffi; Georg Behrens; Anton Pozniak; José Gatell; Esteban Martínez; Linos Vandekerckhove; Els Caluwé; Stephane de Wit; Coca Necsoi; Eric Florence; Maartje van Frankenhuijsen; François Raffi; Clotilde Allavena; Véronique Reliquet; David Boutoille; Morane Cavellec; Elisabeth André-Garnier; Audrey Rodallec; Thierry Le Tourneau; Jérôme Connault; Jean-Michel Molina; Samuel Ferret; Miresta Previlon; Yazdan Yazdanpanah; Roland Landman; Véronique Joly; Adriana Pinto; Christine Katlama; Fabienne Caby; Nadine Ktorza; Luminita Schneider; Christoph Stephan; Timo Wolf; Gundolf Schüttfort; Juergen Rockstroh; Jan-Christian Wasmuth; Carolynne Schwarze-Zander; Christoph Boesecke; Hans-Jurgen Stellbrink; Christian Hoffmann; Michael Sabranski; Stephan Esser; Robert Jablonka; Heidi Wiehler; Georg Behrens; Matthias Stoll; Gerrit Ahrenstorf; Giovanni Guaraldi; Giulia Nardini; Barbara Beghetto; Antonella D’arminio Montforte; Teresa Bini; Viola Cogliandro; Massimo Di Pietro; Francesco Maria Fusco; Massimo Galli; Stefano Rusconi; Andrea Giacomelli; Paola Meraviglia; Esteban Martinez; Ana González-Cordón; José Maria Gatell; Berta Torres; Pere Domingo; Gracia Mateo; Mar Gutierrez; Joaquin Portilla; Esperanza Merino; Sergio Reus; Vicente Boix; Mar Masia; Félix Gutiérrez; Sergio Padilla; Bonaventura Clotet; Eugenia Negredo; Anna Bonjoch; José Casado; Sara Bañón-Escandell; Jose Saban; Africa Duque; Daniel Podzamczer; Maria Saumoy; Laura Acerete; Juan Gonzalez-Garcia; José Ignacio Bernardino; José Ramón Arribas; Victor Hontañón; Graeme Moyle; Nicole Pagani; Margherita Bracchi; Jaime Vera; Amanda Clarke; Tanya Adams; Celia Richardson; Alan Winston; Borja Mora-Peris; Scott Mullaney; Laura Waters; Nahum de Esteban; Ana Milinkovic; Sarah Pett; Julie Fox; Juan Manuel Tiraboschi; Margaret Johnson; Mike Youle; Chloe Orkin; Simon Rackstraw; James Hand; Mark Gompels; Louise Jennings; Jane Nicholls; Sarah Johnston

doi:10.1093/jac/dkab158

Journal Articles Journal of Antimicrobial Chemotherapy Year : 2021

Switching from boosted PIs to dolutegravir decreases soluble CD14 and adiponectin in high cardiovascular risk people living with HIV

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Ana González-Cordón

Function : Author

Institut d'Investigacions Biomèdiques August Pi i Sunyer

Lambert Assoumou

Function : Author

Stratégies thérapeutiques contre l'infection VIH et les maladies virales associées [iPLesp]

Graeme Moyle

Function : Author

Chelsea and Westminster Hospital

Laura Waters

Function : Author

Central and North West London NHS Foundation Trust [London, UK]

Margaret Johnson

Function : Author

Royal Free London NHS Foundation Trust

Pere Domingo

Function : Author
PersonId : 1151293
ORCID : 0000-0003-1138-5770

Hospital de la Santa Creu i Sant Pau

Julie Fox

Function : Author

Guy's and St Thomas' NHS Foundation Trust

Hans-Jürgen Stellbrink

Function : Author

Infektionsmedizinisches Study Centrum

Giovanni Guaraldi

Function : Author
PersonId : 1150952
ORCID : 0000-0002-5724-3914

Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia

Mar Masiá

Function : Author
PersonId : 1151294
ORCID : 0000-0001-9878-2458

Hospital General Universitario de Elche

Mark Gompels

Function : Author

North Bristol NHS Trust [Bristol, UK]

Stephane de Wit

Function : Author

Université libre de Bruxelles

Eric Florence

Function : Author

Ziekenhuis Netwerk Antwerpen

Stefan Esser

Function : Author

Universitätsklinikum Essen [Universität Duisburg-Essen]

François Raffi

Function : Author

Centre Hospitalier Universitaire de Nantes = Nantes University Hospital

Georg Behrens

Function : Author

Medizinische Hochschule Hannover = Hannover Medical School

Anton Pozniak

Function : Author

Chelsea and Westminster Hospital

José Gatell

Function : Author

Institut d'Investigacions Biomèdiques August Pi i Sunyer

ViiV Healthcare [Brentford, UK]

Esteban Martínez

Function : Author

Institut d'Investigacions Biomèdiques August Pi i Sunyer

Linos Vandekerckhove

Function : Author

Els Caluwé

Function : Author

Stephane de Wit

Function : Author

Coca Necsoi

Function : Author

Eric Florence

Function : Author

Maartje van Frankenhuijsen

Function : Author

François Raffi

Function : Author

Clotilde Allavena

Function : Author

Véronique Reliquet

Function : Author

David Boutoille

Function : Author

Morane Cavellec

Function : Author

Elisabeth André-Garnier

Function : Author

Audrey Rodallec

Function : Author

Thierry Le Tourneau

Function : Author

Jérôme Connault

Function : Author

Jean-Michel Molina

Function : Author

Samuel Ferret

Function : Author

Miresta Previlon

Function : Author

Yazdan Yazdanpanah

Function : Author

Roland Landman

Function : Author

Véronique Joly

Function : Author

Adriana Pinto

Function : Author

Christine Katlama

Function : Author

Fabienne Caby

Function : Author

Nadine Ktorza

Function : Author

Luminita Schneider

Function : Author

Christoph Stephan

Function : Author

Timo Wolf

Function : Author

Gundolf Schüttfort

Function : Author

Juergen Rockstroh

Function : Author

Jan-Christian Wasmuth

Function : Author

Carolynne Schwarze-Zander

Function : Author

Christoph Boesecke

Function : Author

Hans-Jurgen Stellbrink

Function : Author

Christian Hoffmann

Function : Author

Michael Sabranski

Function : Author

Stephan Esser

Function : Author

Robert Jablonka

Function : Author

Heidi Wiehler

Function : Author

Georg Behrens

Function : Author

Matthias Stoll

Function : Author

Gerrit Ahrenstorf

Function : Author

Giovanni Guaraldi

Function : Author

Giulia Nardini

Function : Author

Barbara Beghetto

Function : Author

Antonella D’arminio Montforte

Function : Author

Teresa Bini

Function : Author

Viola Cogliandro

Function : Author

Massimo Di Pietro

Function : Author

Francesco Maria Fusco

Function : Author

Massimo Galli

Function : Author

Stefano Rusconi

Function : Author

Andrea Giacomelli

Function : Author

Paola Meraviglia

Function : Author

Esteban Martinez

Function : Author

Ana González-Cordón

Function : Author

José Maria Gatell

Function : Author

Berta Torres

Function : Author

Pere Domingo

Function : Author

Gracia Mateo

Function : Author

Mar Gutierrez

Function : Author

Joaquin Portilla

Function : Author

Esperanza Merino

Function : Author

Sergio Reus

Function : Author

Vicente Boix

Function : Author

Mar Masia

Function : Author

Félix Gutiérrez

Function : Author

Sergio Padilla

Function : Author

Bonaventura Clotet

Function : Author

Eugenia Negredo

Function : Author

Anna Bonjoch

Function : Author

José Casado

Function : Author

Sara Bañón-Escandell

Function : Author

Jose Saban

Function : Author

Africa Duque

Function : Author

Daniel Podzamczer

Function : Author

Maria Saumoy

Function : Author

Laura Acerete

Function : Author

Juan Gonzalez-Garcia

Function : Author

José Ignacio Bernardino

Function : Author

José Ramón Arribas

Function : Author

Victor Hontañón

Function : Author

Graeme Moyle

Function : Author

Nicole Pagani

Function : Author

Margherita Bracchi

Function : Author

Jaime Vera

Function : Author

Amanda Clarke

Function : Author

Tanya Adams

Function : Author

Celia Richardson

Function : Author

Alan Winston

Function : Author

Borja Mora-Peris

Function : Author

Scott Mullaney

Function : Author

Laura Waters

Function : Author

Nahum de Esteban

Function : Author

Ana Milinkovic

Function : Author

Sarah Pett

Function : Author

Julie Fox

Function : Author

Juan Manuel Tiraboschi

Function : Author

Margaret Johnson

Function : Author

Mike Youle

Function : Author

Chloe Orkin

Function : Author

Simon Rackstraw

Function : Author

James Hand

Function : Author

Mark Gompels

Function : Author

Louise Jennings

Function : Author

Jane Nicholls

Function : Author

Sarah Johnston

Function : Author

Abstract

Background: Switching from boosted PIs to dolutegravir in people living with HIV (PLWH) with high cardiovascular risk improved plasma lipids at 48 weeks in the NEAT022 trial. Whether this strategy may have an impact on cardiovascular biomarkers is unknown. Methods: We assessed 48 week changes in biomarkers associated with inflammation, endothelial dysfunction, monocyte immune activation, oxidation, insulin resistance, hypercoagulability, heart failure, myocardial injury, and glomerular and tubular kidney injury. Results: Of 415 PLWH randomized in the NEAT022 study, 313 (75.4%) remained on allocated therapy and had paired samples available. Soluble CD14 (-11%, P < 0.001) and adiponectin (-11%, P < 0.001) significantly declined and high-sensitive C-reactive protein (-13%, P = 0.069) and oxidized LDL (-13%, P = 0.084) tended to decrease with dolutegravir. Switching to dolutegravir remained significantly associated with soluble CD14 and adiponectin reductions after adjustment for baseline variables. There were inverse correlations between soluble CD14 and CD4 count changes (P = 0.05), and between adiponectin and BMI changes (P < 0.001). Conclusions: Switching from boosted PIs to dolutegravir in PLWH with high cardiovascular risk led to soluble CD14 and adiponectin reductions at 48 weeks. While decreasing soluble CD14 may entail favourable health effects in PLWH, adiponectin reduction may reflect less insulin sensitivity associated with weight gain.

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Life Sciences [q-bio]

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https://hal.sorbonne-universite.fr/hal-03732525

Submitted on : Thursday, July 21, 2022-10:21:10 AM

Last modification on : Monday, December 2, 2024-4:52:34 PM

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hal-03732525 , version 1 (21-07-2022)

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HAL Id : hal-03732525 , version 1
DOI : 10.1093/jac/dkab158

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Ana González-Cordón, Lambert Assoumou, Graeme Moyle, Laura Waters, Margaret Johnson, et al.. Switching from boosted PIs to dolutegravir decreases soluble CD14 and adiponectin in high cardiovascular risk people living with HIV. Journal of Antimicrobial Chemotherapy, 2021, 76 (9), pp.2380-2393. ⟨10.1093/jac/dkab158⟩. ⟨hal-03732525⟩

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Switching from boosted PIs to dolutegravir decreases soluble CD14 and adiponectin in high cardiovascular risk people living with HIV

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