Overexpression of Canonical Prefoldin Associates with the Risk of Mortality and Metastasis in Non-Small Cell Lung Cancer - Sorbonne Université
Journal Articles Cancers Year : 2020

Overexpression of Canonical Prefoldin Associates with the Risk of Mortality and Metastasis in Non-Small Cell Lung Cancer

Juan Manuel Praena-Fernández
Pedro Romero Pareja
  • Function : Author
María del Valle Enguix-Riego
  • Function : Author
Laura Payán-Bravo
  • Function : Author
Begoña Vieites
  • Function : Author
Lourdes Gomez-Izquierdo
Javier Jaen Olasolo
  • Function : Author
Eleonor Rivin del Campo
Jose Carlos Reyes
  • Function : Author
Jose Luis Lopez Guerra

Abstract

Canonical prefoldin is a protein cochaperone composed of six different subunits (PFDN1 to 6). PFDN1 overexpression promotes epithelial–mesenchymal transition (EMT) and increases the growth of xenograft lung cancer (LC) cell lines. We investigated whether this putative involvement of canonical PFDN in LC translates into the clinic. First, the mRNA expression of 518 non-small cell LC (NSCLC) cases from The Cancer Genome Atlas (TCGA) database was evaluated. Patients with PFDN1 overexpression had lower overall survival (OS; 45 vs. 86 months; p = 0.034). We then assessed the impact of PFDN expression on outcome in 58 NSCLC patients with available tumor tissue samples. PFDN1, 3, and 5 overexpression were found in 38% (n = 22), 53% (n = 31), and 41% (n = 24) of tumor samples. PFDN1, 3, and 5 overexpression were significantly associated with lower OS, lower disease-free survival (DFS), and lower distant metastasis-free survival (DMFS) for PFDN1 and 3 with a trend for PFDN5. In multivariate analysis, PFDN5 retained significance for OS (hazard ratio (HR) 2.56; p = 0.007) and PFDN1 for DFS (HR 2.53; p = 0.010) and marginally for DMFS (HR 2.32; p = 0.053). Our results indicate that protein response markers, such as PFDN1, 3, and 5, may complement mRNA signatures and be useful for determining the most appropriate therapy for NSCLC patients.

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Cancer
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Dates and versions

hal-03766989 , version 1 (01-09-2022)

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Xenia Peñate, Juan Manuel Praena-Fernández, Pedro Romero Pareja, María del Valle Enguix-Riego, Laura Payán-Bravo, et al.. Overexpression of Canonical Prefoldin Associates with the Risk of Mortality and Metastasis in Non-Small Cell Lung Cancer. Cancers, 2020, 12 (4), pp.1052. ⟨10.3390/cancers12041052⟩. ⟨hal-03766989⟩
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