Similar 5-year HCC occurrence in Tenofovir- and Entecavir-treated HBV chronic infection in the French AFEF/ANRS CO22 Hepather cohort.

Stanislas Pol; Delphine Bonnet; Virginie Payssan-Sicart; Chloe Pomes; François Bailly; Marjolaine Beaudoin; Dominique Giboz; Kerstin Hartig-Lavie; Marianne Maynard; Eric Billaud; David Boutoille; Morane Cavellec; Caroline Chevalier; Isabelle Hubert; Pierre Goepfert; Adrien Lannes; François Lunel; Jérôme Boursier; Nathalie Boyer; Nathalie Giuily; Corinne Castelnau; Giovanna Scoazec; Aziza Chibah; Sylvie Keser; Karim Bonardi; Anaïs Vallet-Pichard; Philippe Sogni; Juliette Foucher; Jean-Baptiste Hiriart; Amandine Legendre; Faiza Chermak; Marie Irlès-Depé; Si Nafa Si Ahmed; Christelle Ansaldi; Nisserine Ben Amara; Valérie Oules; Jacqueline Dunette; Rodolphe Anty; Eve Gelsi; Régin Truchi; Elena Luckina; Nadia Messaoudi; Joseph Moussali; Barbara De Dieuleveult; Héloïse Goin; Damien Labarrière; Pascal Potier; Si Nafa Si Ahmed; Véronique Grando-Lemaire; Pierre Nahon; Séverin Brulé; Rym Monard; Caroline Jezequel; Audrey Brener; Anne Laligant; Aline Rabot; Isabelle Renard; Thomas F Baumert; Michel Dofföel; Catherine Mutter; Pauline Simo-Noumbissie; Esma Razi; Hélène Barraud; Mouni Bensenane; Abdelbasset Nani; Sarah Hassani-Nani; Marie-Albertine Bernard; Georges-Philippe Pageaux; Michael Bismuth; Ludovic Caillo; Stéphani Faure; Marie Pierre Ripault; Christophe Bureau; Sarah Launay; Jean Marie Peron; Marie Angèl Robic; Lé Tarallo; Marine Faure; Bruno Froissart; Marie-Noelle Hilleret; Jean-Pierre Zarski; Odile Goria; Victorien Grard; Hélè E Montialoux; Muriel François; Christian Ouedraogo; Christelle Pauleau; Anne Varault; Tony Andreani; Bénédic E Angoulevant; Azeline Chevance; Lawrence Serfaty; Teresa Antonini; Audrey Coilly; Jean-Charles Duclos Vallée; Mariagrazia Tateo; Corinne Bonny; Chanteranne Brigitte; Géraldin Lamblin; Léo Muti; Abdenour Babouri; Virginie Filipe; Camille Barrault; Laurent Costes; Soraya Merbah; Paul Carrier; Maryline Debette-Gratien; Jérémie Jacques; Guillaume Lassailly; Florent Artu; Valérie Canva; Sébastie Dharancy; Alexandre Louvet; Marianne Latournerie; Marc Bardou; Thomas Mouillot; Yannick Bacq; Didier Barbereau; Charlotte Nicolas; Caroline Chevalier; Isabelle Archambeaud; Sarah Habes; Nisserine Ben Amara; Danièl Botta-Fridlund; Eric Saillard; Marie-José Lafrance; Clovis Luzivika Nzinga; Céline Dorival; Fabien Zoulim; Carole Cagnot; Thomas Decaens; Dominique Thabut; Tarik Asselah; Philippe Mathurin; Nathalie Ganne; Didier Samuel; Françoi Habersetzer; Jean-Pierre Bronowicki; Dominique Guyader; Isabelle Rosa; Vincent Leroy; Olivier Chazouilleres; Victor De Ledinghen; Marc Bourliere; Xavier Causse; Paul Cales; Sophie Metivier; Véroniqu Loustaud-Ratti; Armand Abergel; Hélène Fontaine; Fabrice Carrat

doi:10.1111/apt.16197

Journal Articles Alimentary Pharmacology & Therapeutics (Suppl) Year : 2021

Similar 5-year HCC occurrence in Tenofovir- and Entecavir-treated HBV chronic infection in the French AFEF/ANRS CO22 Hepather cohort.

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Stanislas Pol

Function : Author

Département d'hépatologie [CHU Cochin]

Physiopathologie du système immunitaire

Delphine Bonnet

Function : Author

Virginie Payssan-Sicart

Function : Author

Chloe Pomes

Function : Author

François Bailly

Function : Author

Marjolaine Beaudoin

Function : Author

Dominique Giboz

Function : Author

Kerstin Hartig-Lavie

Function : Author

Marianne Maynard

Function : Author

Eric Billaud

Function : Author

David Boutoille

Function : Author

Morane Cavellec

Function : Author

Caroline Chevalier

Function : Author

Isabelle Hubert

Function : Author

Pierre Goepfert

Function : Author

Adrien Lannes

Function : Author

François Lunel

Function : Author

Jérôme Boursier

Function : Author

Nathalie Boyer

Function : Author

Nathalie Giuily

Function : Author

Corinne Castelnau

Function : Author

Giovanna Scoazec

Function : Author

Aziza Chibah

Function : Author

Sylvie Keser

Function : Author

Karim Bonardi

Function : Author

Anaïs Vallet-Pichard

Function : Author

Philippe Sogni

Function : Author

Juliette Foucher

Function : Author

Jean-Baptiste Hiriart

Function : Author

Amandine Legendre

Function : Author

Faiza Chermak

Function : Author

Marie Irlès-Depé

Function : Author

Si Nafa Si Ahmed

Function : Author

Christelle Ansaldi

Function : Author

Nisserine Ben Amara

Function : Author

Valérie Oules

Function : Author

Jacqueline Dunette

Function : Author

Rodolphe Anty

Function : Author

Eve Gelsi

Function : Author

Régin Truchi

Function : Author

Elena Luckina

Function : Author

Nadia Messaoudi

Function : Author

Joseph Moussali

Function : Author

Barbara De Dieuleveult

Function : Author

Héloïse Goin

Function : Author

Damien Labarrière

Function : Author

Pascal Potier

Function : Author

Si Nafa Si Ahmed

Function : Author

Véronique Grando-Lemaire

Function : Author

Pierre Nahon

Function : Author

Séverin Brulé

Function : Author

Rym Monard

Function : Author

Caroline Jezequel

Function : Author

Audrey Brener

Function : Author

Anne Laligant

Function : Author

Aline Rabot

Function : Author

Isabelle Renard

Function : Author

Thomas F Baumert

Function : Author

Michel Dofföel

Function : Author

Catherine Mutter

Function : Author

Pauline Simo-Noumbissie

Function : Author

Esma Razi

Function : Author

Hélène Barraud

Function : Author

Mouni Bensenane

Function : Author

Abdelbasset Nani

Function : Author

Sarah Hassani-Nani

Function : Author

Marie-Albertine Bernard

Function : Author

Georges-Philippe Pageaux

Function : Author

Michael Bismuth

Function : Author

Ludovic Caillo

Function : Author

Stéphani Faure

Function : Author

Marie Pierre Ripault

Function : Author

Christophe Bureau

Function : Author

Sarah Launay

Function : Author

Jean Marie Peron

Function : Author

Marie Angèl Robic

Function : Author

Lé Tarallo

Function : Author

Marine Faure

Function : Author

Bruno Froissart

Function : Author

Marie-Noelle Hilleret

Function : Author

Jean-Pierre Zarski

Function : Author

Odile Goria

Function : Author

Victorien Grard

Function : Author

Hélè E Montialoux

Function : Author

Muriel François

Function : Author

Christian Ouedraogo

Function : Author

Christelle Pauleau

Function : Author

Anne Varault

Function : Author

Tony Andreani

Function : Author

Bénédic E Angoulevant

Function : Author

Azeline Chevance

Function : Author

Lawrence Serfaty

Function : Author

Teresa Antonini

Function : Author

Audrey Coilly

Function : Author

Jean-Charles Duclos Vallée

Function : Author

Mariagrazia Tateo

Function : Author

Corinne Bonny

Function : Author

Chanteranne Brigitte

Function : Author

Géraldin Lamblin

Function : Author

Léo Muti

Function : Author

Abdenour Babouri

Function : Author

Virginie Filipe

Function : Author

Camille Barrault

Function : Author

Laurent Costes

Function : Author

Soraya Merbah

Function : Author

Paul Carrier

Function : Author

Maryline Debette-Gratien

Function : Author

Jérémie Jacques

Function : Author

Guillaume Lassailly

Function : Author

Florent Artu

Function : Author

Valérie Canva

Function : Author

Sébastie Dharancy

Function : Author

Alexandre Louvet

Function : Author

Marianne Latournerie

Function : Author

Marc Bardou

Function : Author

Thomas Mouillot

Function : Author

Yannick Bacq

Function : Author

Didier Barbereau

Function : Author

Charlotte Nicolas

Function : Author

Caroline Chevalier

Function : Author

Isabelle Archambeaud

Function : Author

Sarah Habes

Function : Author

Nisserine Ben Amara

Function : Author

Danièl Botta-Fridlund

Function : Author

Eric Saillard

Function : Author

Marie-José Lafrance

Function : Author

Clovis Luzivika Nzinga

Function : Author

Institut Pierre Louis d'Epidémiologie et de Santé Publique

Céline Dorival

Function : Author

Institut Pierre Louis d'Epidémiologie et de Santé Publique

Fabien Zoulim

Function : Author
PersonId : 890662
IdHAL : fabien-zoulim
ORCID : 0000-0002-2245-0083

Carole Cagnot

Function : Author

Thomas Decaens

Function : Author

Dominique Thabut

Function : Author

Tarik Asselah

Function : Author

Philippe Mathurin

Function : Author
PersonId : 903127
ORCID : 0000-0003-3447-2025

Nathalie Ganne

Function : Author

Didier Samuel

Function : Author

Françoi Habersetzer

Function : Author

Jean-Pierre Bronowicki

Function : Author

Dominique Guyader

Function : Author

Isabelle Rosa

Function : Author

Vincent Leroy

Function : Author

Olivier Chazouilleres

Function : Author

Victor De Ledinghen

Function : Author

Marc Bourliere

Function : Author

Xavier Causse

Function : Author

Paul Cales

Function : Author
PersonId : 759545
ORCID : 0000-0003-4866-5274
IdRef : 06952680X

Sophie Metivier

Function : Author

Véroniqu Loustaud-Ratti

Function : Author

Armand Abergel

Function : Author
PersonId : 763073
ORCID : 0000-0001-7480-1052
IdRef : 109301269

Hélène Fontaine

Function : Author

Fabrice Carrat

Function : Author

Institut Pierre Louis d'Epidémiologie et de Santé Publique

Abstract

Background: Chronic hepatitis B virus (HBV) infection results in a high risk of cirrhosis and its complications, cirrhosis decompensation (DC), hepatocellular carcinoma (HCC), liver transplantation (LT), death or any of these outcomes (composite endpoint [CE]). Nucleos(t)ide analogues (NUCs) such as tenofovir or entecavir are associated with a reduction in these complications. Aim: To compare the impact of tenofovir and entecavir on these outcomes in patients treated for HBV infection and included in the prospective Hepather cohort. Methods: All patients with HBV infection who had received tenofovir or entecavir for more than 6 months at or after entry in the ANRS CO22 cohort were selected. Patients with HDV and HCV co-infection or prior liver event were excluded. Incidence rates of events were compared using inverse probability of treatment weighting (IPW). Results: The cohort included 1800 patients (986 tenofovir and 814 entecavir). Median follow-up was 4.2 years. The incidences of HCC, DC, LT, ACD, LRD and CE were not different between tenofovir- (1.8 (0.9; 3.2), 0.6 (0.2; 1.6), 0.2 (0.0; 0.8), 1.7 (0.8; 3.0), 0.8 (0.2, 1.8) and 4.1 (3.0; 5.4) per 1000 person-years) and entecavir-treated patients (1.6 (0.7; 3.0), 0.7 (0.2; 1.8), 0.2 (0.0; 1.0), 3.0 (1.7, 4.8), 0.5 (0.1; 1.5) and 5.0 (3.3; 7.2)) per 1000 person-years, respectively. Conclusion: The risk of liver-related events or death was not different between tenofovir- and entecavir-treated patients in this large prospective cohort of predominantly non-cirrhotic French patients. Trial registration number: NCT019553458.

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Santé publique et épidémiologie

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Submitted on : Friday, September 23, 2022-1:45:47 PM

Last modification on : Tuesday, September 3, 2024-3:04:21 PM

Long-term archiving on: Saturday, December 24, 2022-6:47:12 PM

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hal-03784807 , version 1 (23-09-2022)

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HAL Id : hal-03784807 , version 1
DOI : 10.1111/apt.16197
PUBMED : 33464621

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Stanislas Pol, Delphine Bonnet, Virginie Payssan-Sicart, Chloe Pomes, François Bailly, et al.. Similar 5-year HCC occurrence in Tenofovir- and Entecavir-treated HBV chronic infection in the French AFEF/ANRS CO22 Hepather cohort.. Alimentary Pharmacology & Therapeutics (Suppl), 2021, 53 (5), pp.616-629. ⟨10.1111/apt.16197⟩. ⟨hal-03784807⟩

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Similar 5-year HCC occurrence in Tenofovir- and Entecavir-treated HBV chronic infection in the French AFEF/ANRS CO22 Hepather cohort.

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