Similar 5-year HCC occurrence in Tenofovir- and Entecavir-treated HBV chronic infection in the French AFEF/ANRS CO22 Hepather cohort. - Sorbonne Université Access content directly
Journal Articles Alimentary Pharmacology & Therapeutics (Suppl) Year : 2021

Similar 5-year HCC occurrence in Tenofovir- and Entecavir-treated HBV chronic infection in the French AFEF/ANRS CO22 Hepather cohort.

Stanislas Pol (1, 2) , Delphine Bonnet , Virginie Payssan-Sicart , Chloe Pomes , François Bailly , Marjolaine Beaudoin , Dominique Giboz , Kerstin Hartig-Lavie , Marianne Maynard , Eric Billaud , David Boutoille , Morane Cavellec , Caroline Chevalier , Isabelle Hubert , Pierre Goepfert , Adrien Lannes , François Lunel , Jérôme Boursier , Nathalie Boyer , Nathalie Giuily , Corinne Castelnau , Giovanna Scoazec , Aziza Chibah , Sylvie Keser , Karim Bonardi , Anaïs Vallet-Pichard , Philippe Sogni , Juliette Foucher , Jean-Baptiste Hiriart , Amandine Legendre , Faiza Chermak , Marie Irlès-Depé , Si Nafa Si Ahmed , Christelle Ansaldi , Nisserine Ben Amara , Valérie Oules , Jacqueline Dunette , Rodolphe Anty , Eve Gelsi , Régin Truchi , Elena Luckina , Nadia Messaoudi , Joseph Moussali , Barbara De Dieuleveult , Héloïse Goin , Damien Labarrière , Pascal Potier , Si Nafa Si Ahmed , Véronique Grando-Lemaire , Pierre Nahon , Séverin Brulé , Rym Monard , Caroline Jezequel , Audrey Brener , Anne Laligant , Aline Rabot , Isabelle Renard , Thomas F Baumert , Michel Dofföel , Catherine Mutter , Pauline Simo-Noumbissie , Esma Razi , Hélène Barraud , Mouni Bensenane , Abdelbasset Nani , Sarah Hassani-Nani , Marie-Albertine Bernard , Georges-Philippe Pageaux , Michael Bismuth , Ludovic Caillo , Stéphani Faure , Marie Pierre Ripault , Christophe Bureau , Sarah Launay , Jean Marie Peron , Marie Angèl Robic , Lé Tarallo , Marine Faure , Bruno Froissart , Marie-Noelle Hilleret , Jean-Pierre Zarski , Odile Goria , Victorien Grard , Hélè E Montialoux , Muriel François , Christian Ouedraogo , Christelle Pauleau , Anne Varault , Tony Andreani , Bénédic E Angoulevant , Azeline Chevance , Lawrence Serfaty , Teresa Antonini , Audrey Coilly , Jean-Charles Duclos Vallée , Mariagrazia Tateo , Corinne Bonny , Chanteranne Brigitte , Géraldin Lamblin , Léo Muti , Abdenour Babouri , Virginie Filipe , Camille Barrault , Laurent Costes , Soraya Merbah , Paul Carrier , Maryline Debette-Gratien , Jérémie Jacques , Guillaume Lassailly , Florent Artu , Valérie Canva , Sébastie Dharancy , Alexandre Louvet , Marianne Latournerie , Marc Bardou , Thomas Mouillot , Yannick Bacq , Didier Barbereau , Charlotte Nicolas , Caroline Chevalier , Isabelle Archambeaud , Sarah Habes , Nisserine Ben Amara , Danièl Botta-Fridlund , Eric Saillard , Marie-José Lafrance , Clovis Luzivika Nzinga (3) , Céline Dorival (3) , Fabien Zoulim , Carole Cagnot , Thomas Decaens , Dominique Thabut , Tarik Asselah , Philippe Mathurin , Nathalie Ganne , Didier Samuel , Françoi Habersetzer , Jean-Pierre Bronowicki , Dominique Guyader , Isabelle Rosa , Vincent Leroy , Olivier Chazouilleres , Victor De Ledinghen , Marc Bourliere , Xavier Causse , Paul Cales , Sophie Metivier , Véroniqu Loustaud-Ratti , Armand Abergel , Hélène Fontaine , Fabrice Carrat (3)
Delphine Bonnet
  • Function : Author
Virginie Payssan-Sicart
  • Function : Author
Chloe Pomes
  • Function : Author
François Bailly
  • Function : Author
Marjolaine Beaudoin
  • Function : Author
Dominique Giboz
  • Function : Author
Kerstin Hartig-Lavie
  • Function : Author
Marianne Maynard
  • Function : Author
Eric Billaud
  • Function : Author
David Boutoille
  • Function : Author
Morane Cavellec
  • Function : Author
Caroline Chevalier
  • Function : Author
Isabelle Hubert
  • Function : Author
Pierre Goepfert
  • Function : Author
Adrien Lannes
  • Function : Author
François Lunel
  • Function : Author
Jérôme Boursier
  • Function : Author
Nathalie Boyer
  • Function : Author
Nathalie Giuily
  • Function : Author
Corinne Castelnau
  • Function : Author
Giovanna Scoazec
  • Function : Author
Aziza Chibah
  • Function : Author
Sylvie Keser
  • Function : Author
Karim Bonardi
  • Function : Author
Anaïs Vallet-Pichard
  • Function : Author
Philippe Sogni
  • Function : Author
Juliette Foucher
  • Function : Author
Jean-Baptiste Hiriart
  • Function : Author
Amandine Legendre
  • Function : Author
Faiza Chermak
  • Function : Author
Marie Irlès-Depé
  • Function : Author
Si Nafa Si Ahmed
  • Function : Author
Christelle Ansaldi
  • Function : Author
Nisserine Ben Amara
  • Function : Author
Valérie Oules
  • Function : Author
Jacqueline Dunette
  • Function : Author
Rodolphe Anty
  • Function : Author
Eve Gelsi
  • Function : Author
Régin Truchi
  • Function : Author
Elena Luckina
  • Function : Author
Nadia Messaoudi
  • Function : Author
Joseph Moussali
  • Function : Author
Barbara De Dieuleveult
  • Function : Author
Héloïse Goin
  • Function : Author
Damien Labarrière
  • Function : Author
Pascal Potier
  • Function : Author
Si Nafa Si Ahmed
  • Function : Author
Véronique Grando-Lemaire
  • Function : Author
Pierre Nahon
  • Function : Author
Séverin Brulé
  • Function : Author
Rym Monard
  • Function : Author
Caroline Jezequel
  • Function : Author
Audrey Brener
  • Function : Author
Anne Laligant
  • Function : Author
Aline Rabot
  • Function : Author
Isabelle Renard
  • Function : Author
Thomas F Baumert
  • Function : Author
Michel Dofföel
  • Function : Author
Catherine Mutter
  • Function : Author
Pauline Simo-Noumbissie
  • Function : Author
Esma Razi
  • Function : Author
Hélène Barraud
  • Function : Author
Mouni Bensenane
  • Function : Author
Abdelbasset Nani
  • Function : Author
Sarah Hassani-Nani
  • Function : Author
Marie-Albertine Bernard
  • Function : Author
Georges-Philippe Pageaux
  • Function : Author
Michael Bismuth
  • Function : Author
Ludovic Caillo
  • Function : Author
Stéphani Faure
  • Function : Author
Marie Pierre Ripault
  • Function : Author
Christophe Bureau
  • Function : Author
Sarah Launay
  • Function : Author
Jean Marie Peron
  • Function : Author
Marie Angèl Robic
  • Function : Author
Lé Tarallo
  • Function : Author
Marine Faure
  • Function : Author
Bruno Froissart
  • Function : Author
Marie-Noelle Hilleret
  • Function : Author
Jean-Pierre Zarski
  • Function : Author
Odile Goria
  • Function : Author
Victorien Grard
  • Function : Author
Hélè E Montialoux
  • Function : Author
Muriel François
  • Function : Author
Christian Ouedraogo
  • Function : Author
Christelle Pauleau
  • Function : Author
Anne Varault
  • Function : Author
Tony Andreani
  • Function : Author
Bénédic E Angoulevant
  • Function : Author
Azeline Chevance
  • Function : Author
Lawrence Serfaty
  • Function : Author
Teresa Antonini
  • Function : Author
Audrey Coilly
  • Function : Author
Jean-Charles Duclos Vallée
  • Function : Author
Mariagrazia Tateo
  • Function : Author
Corinne Bonny
  • Function : Author
Chanteranne Brigitte
  • Function : Author
Géraldin Lamblin
  • Function : Author
Léo Muti
  • Function : Author
Abdenour Babouri
  • Function : Author
Virginie Filipe
  • Function : Author
Camille Barrault
  • Function : Author
Laurent Costes
  • Function : Author
Soraya Merbah
  • Function : Author
Paul Carrier
  • Function : Author
Maryline Debette-Gratien
  • Function : Author
Jérémie Jacques
  • Function : Author
Guillaume Lassailly
  • Function : Author
Florent Artu
  • Function : Author
Valérie Canva
  • Function : Author
Sébastie Dharancy
  • Function : Author
Alexandre Louvet
  • Function : Author
Marianne Latournerie
  • Function : Author
Marc Bardou
  • Function : Author
Thomas Mouillot
  • Function : Author
Yannick Bacq
  • Function : Author
Didier Barbereau
  • Function : Author
Charlotte Nicolas
  • Function : Author
Caroline Chevalier
  • Function : Author
Isabelle Archambeaud
  • Function : Author
Sarah Habes
  • Function : Author
Nisserine Ben Amara
  • Function : Author
Danièl Botta-Fridlund
  • Function : Author
Eric Saillard
  • Function : Author
Marie-José Lafrance
  • Function : Author
Fabien Zoulim
Carole Cagnot
  • Function : Author
Thomas Decaens
  • Function : Author
Dominique Thabut
  • Function : Author
Tarik Asselah
  • Function : Author
Philippe Mathurin
Nathalie Ganne
  • Function : Author
Didier Samuel
  • Function : Author
Françoi Habersetzer
  • Function : Author
Jean-Pierre Bronowicki
  • Function : Author
Dominique Guyader
  • Function : Author
Isabelle Rosa
  • Function : Author
Vincent Leroy
  • Function : Author
Olivier Chazouilleres
  • Function : Author
Victor De Ledinghen
  • Function : Author
Marc Bourliere
  • Function : Author
Xavier Causse
  • Function : Author
Paul Cales
Sophie Metivier
  • Function : Author
Véroniqu Loustaud-Ratti
  • Function : Author
Armand Abergel
Hélène Fontaine
  • Function : Author

Abstract

Background: Chronic hepatitis B virus (HBV) infection results in a high risk of cirrhosis and its complications, cirrhosis decompensation (DC), hepatocellular carcinoma (HCC), liver transplantation (LT), death or any of these outcomes (composite endpoint [CE]). Nucleos(t)ide analogues (NUCs) such as tenofovir or entecavir are associated with a reduction in these complications. Aim: To compare the impact of tenofovir and entecavir on these outcomes in patients treated for HBV infection and included in the prospective Hepather cohort. Methods: All patients with HBV infection who had received tenofovir or entecavir for more than 6 months at or after entry in the ANRS CO22 cohort were selected. Patients with HDV and HCV co-infection or prior liver event were excluded. Incidence rates of events were compared using inverse probability of treatment weighting (IPW). Results: The cohort included 1800 patients (986 tenofovir and 814 entecavir). Median follow-up was 4.2 years. The incidences of HCC, DC, LT, ACD, LRD and CE were not different between tenofovir- (1.8 (0.9; 3.2), 0.6 (0.2; 1.6), 0.2 (0.0; 0.8), 1.7 (0.8; 3.0), 0.8 (0.2, 1.8) and 4.1 (3.0; 5.4) per 1000 person-years) and entecavir-treated patients (1.6 (0.7; 3.0), 0.7 (0.2; 1.8), 0.2 (0.0; 1.0), 3.0 (1.7, 4.8), 0.5 (0.1; 1.5) and 5.0 (3.3; 7.2)) per 1000 person-years, respectively. Conclusion: The risk of liver-related events or death was not different between tenofovir- and entecavir-treated patients in this large prospective cohort of predominantly non-cirrhotic French patients. Trial registration number: NCT019553458.
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Dates and versions

hal-03784807 , version 1 (23-09-2022)

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Stanislas Pol, Delphine Bonnet, Virginie Payssan-Sicart, Chloe Pomes, François Bailly, et al.. Similar 5-year HCC occurrence in Tenofovir- and Entecavir-treated HBV chronic infection in the French AFEF/ANRS CO22 Hepather cohort.. Alimentary Pharmacology & Therapeutics (Suppl), 2021, 53 (5), pp.616-629. ⟨10.1111/apt.16197⟩. ⟨hal-03784807⟩
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