Similar 5-year HCC occurrence in Tenofovir- and Entecavir-treated HBV chronic infection in the French AFEF/ANRS CO22 Hepather cohort.
Stanislas Pol
(1, 2)
,
Delphine Bonnet
,
Virginie Payssan-Sicart
,
Chloe Pomes
,
François Bailly
,
Marjolaine Beaudoin
,
Dominique Giboz
,
Kerstin Hartig-Lavie
,
Marianne Maynard
,
Eric Billaud
,
David Boutoille
,
Morane Cavellec
,
Caroline Chevalier
,
Isabelle Hubert
,
Pierre Goepfert
,
Adrien Lannes
,
François Lunel
,
Jérôme Boursier
,
Nathalie Boyer
,
Nathalie Giuily
,
Corinne Castelnau
,
Giovanna Scoazec
,
Aziza Chibah
,
Sylvie Keser
,
Karim Bonardi
,
Anaïs Vallet-Pichard
,
Philippe Sogni
,
Juliette Foucher
,
Jean-Baptiste Hiriart
,
Amandine Legendre
,
Faiza Chermak
,
Marie Irlès-Depé
,
Si Nafa Si Ahmed
,
Christelle Ansaldi
,
Nisserine Ben Amara
,
Valérie Oules
,
Jacqueline Dunette
,
Rodolphe Anty
,
Eve Gelsi
,
Régin Truchi
,
Elena Luckina
,
Nadia Messaoudi
,
Joseph Moussali
,
Barbara De Dieuleveult
,
Héloïse Goin
,
Damien Labarrière
,
Pascal Potier
,
Si Nafa Si Ahmed
,
Véronique Grando-Lemaire
,
Pierre Nahon
,
Séverin Brulé
,
Rym Monard
,
Caroline Jezequel
,
Audrey Brener
,
Anne Laligant
,
Aline Rabot
,
Isabelle Renard
,
Thomas F Baumert
,
Michel Dofföel
,
Catherine Mutter
,
Pauline Simo-Noumbissie
,
Esma Razi
,
Hélène Barraud
,
Mouni Bensenane
,
Abdelbasset Nani
,
Sarah Hassani-Nani
,
Marie-Albertine Bernard
,
Georges-Philippe Pageaux
,
Michael Bismuth
,
Ludovic Caillo
,
Stéphani Faure
,
Marie Pierre Ripault
,
Christophe Bureau
,
Sarah Launay
,
Jean Marie Peron
,
Marie Angèl Robic
,
Lé Tarallo
,
Marine Faure
,
Bruno Froissart
,
Marie-Noelle Hilleret
,
Jean-Pierre Zarski
,
Odile Goria
,
Victorien Grard
,
Hélè E Montialoux
,
Muriel François
,
Christian Ouedraogo
,
Christelle Pauleau
,
Anne Varault
,
Tony Andreani
,
Bénédic E Angoulevant
,
Azeline Chevance
,
Lawrence Serfaty
,
Teresa Antonini
,
Audrey Coilly
,
Jean-Charles Duclos Vallée
,
Mariagrazia Tateo
,
Corinne Bonny
,
Chanteranne Brigitte
,
Géraldin Lamblin
,
Léo Muti
,
Abdenour Babouri
,
Virginie Filipe
,
Camille Barrault
,
Laurent Costes
,
Soraya Merbah
,
Paul Carrier
,
Maryline Debette-Gratien
,
Jérémie Jacques
,
Guillaume Lassailly
,
Florent Artu
,
Valérie Canva
,
Sébastie Dharancy
,
Alexandre Louvet
,
Marianne Latournerie
,
Marc Bardou
,
Thomas Mouillot
,
Yannick Bacq
,
Didier Barbereau
,
Charlotte Nicolas
,
Caroline Chevalier
,
Isabelle Archambeaud
,
Sarah Habes
,
Nisserine Ben Amara
,
Danièl Botta-Fridlund
,
Eric Saillard
,
Marie-José Lafrance
,
Clovis Luzivika Nzinga
(3)
,
Céline Dorival
(3)
,
Fabien Zoulim
,
Carole Cagnot
,
Thomas Decaens
,
Dominique Thabut
,
Tarik Asselah
,
Philippe Mathurin
,
Nathalie Ganne
,
Didier Samuel
,
Françoi Habersetzer
,
Jean-Pierre Bronowicki
,
Dominique Guyader
,
Isabelle Rosa
,
Vincent Leroy
,
Olivier Chazouilleres
,
Victor De Ledinghen
,
Marc Bourliere
,
Xavier Causse
,
Paul Cales
,
Sophie Metivier
,
Véroniqu Loustaud-Ratti
,
Armand Abergel
,
Hélène Fontaine
,
Fabrice Carrat
(3)
Delphine Bonnet
- Function : Author
Virginie Payssan-Sicart
- Function : Author
Chloe Pomes
- Function : Author
François Bailly
- Function : Author
Marjolaine Beaudoin
- Function : Author
Dominique Giboz
- Function : Author
Kerstin Hartig-Lavie
- Function : Author
Marianne Maynard
- Function : Author
Eric Billaud
- Function : Author
David Boutoille
- Function : Author
Morane Cavellec
- Function : Author
Caroline Chevalier
- Function : Author
Isabelle Hubert
- Function : Author
Pierre Goepfert
- Function : Author
Adrien Lannes
- Function : Author
François Lunel
- Function : Author
Jérôme Boursier
- Function : Author
Nathalie Boyer
- Function : Author
Nathalie Giuily
- Function : Author
Corinne Castelnau
- Function : Author
Giovanna Scoazec
- Function : Author
Aziza Chibah
- Function : Author
Sylvie Keser
- Function : Author
Karim Bonardi
- Function : Author
Anaïs Vallet-Pichard
- Function : Author
Philippe Sogni
- Function : Author
Juliette Foucher
- Function : Author
Jean-Baptiste Hiriart
- Function : Author
Amandine Legendre
- Function : Author
Faiza Chermak
- Function : Author
Marie Irlès-Depé
- Function : Author
Si Nafa Si Ahmed
- Function : Author
Christelle Ansaldi
- Function : Author
Nisserine Ben Amara
- Function : Author
Valérie Oules
- Function : Author
Jacqueline Dunette
- Function : Author
Rodolphe Anty
- Function : Author
Eve Gelsi
- Function : Author
Régin Truchi
- Function : Author
Elena Luckina
- Function : Author
Nadia Messaoudi
- Function : Author
Joseph Moussali
- Function : Author
Barbara De Dieuleveult
- Function : Author
Héloïse Goin
- Function : Author
Damien Labarrière
- Function : Author
Pascal Potier
- Function : Author
Si Nafa Si Ahmed
- Function : Author
Véronique Grando-Lemaire
- Function : Author
Pierre Nahon
- Function : Author
Séverin Brulé
- Function : Author
Rym Monard
- Function : Author
Caroline Jezequel
- Function : Author
Audrey Brener
- Function : Author
Anne Laligant
- Function : Author
Aline Rabot
- Function : Author
Isabelle Renard
- Function : Author
Thomas F Baumert
- Function : Author
Michel Dofföel
- Function : Author
Catherine Mutter
- Function : Author
Pauline Simo-Noumbissie
- Function : Author
Esma Razi
- Function : Author
Hélène Barraud
- Function : Author
Mouni Bensenane
- Function : Author
Abdelbasset Nani
- Function : Author
Sarah Hassani-Nani
- Function : Author
Marie-Albertine Bernard
- Function : Author
Georges-Philippe Pageaux
- Function : Author
Michael Bismuth
- Function : Author
Ludovic Caillo
- Function : Author
Stéphani Faure
- Function : Author
Marie Pierre Ripault
- Function : Author
Christophe Bureau
- Function : Author
Sarah Launay
- Function : Author
Jean Marie Peron
- Function : Author
Marie Angèl Robic
- Function : Author
Lé Tarallo
- Function : Author
Marine Faure
- Function : Author
Bruno Froissart
- Function : Author
Marie-Noelle Hilleret
- Function : Author
Jean-Pierre Zarski
- Function : Author
Odile Goria
- Function : Author
Victorien Grard
- Function : Author
Hélè E Montialoux
- Function : Author
Muriel François
- Function : Author
Christian Ouedraogo
- Function : Author
Christelle Pauleau
- Function : Author
Anne Varault
- Function : Author
Tony Andreani
- Function : Author
Bénédic E Angoulevant
- Function : Author
Azeline Chevance
- Function : Author
Lawrence Serfaty
- Function : Author
Teresa Antonini
- Function : Author
Audrey Coilly
- Function : Author
Jean-Charles Duclos Vallée
- Function : Author
Mariagrazia Tateo
- Function : Author
Corinne Bonny
- Function : Author
Chanteranne Brigitte
- Function : Author
Géraldin Lamblin
- Function : Author
Léo Muti
- Function : Author
Abdenour Babouri
- Function : Author
Virginie Filipe
- Function : Author
Camille Barrault
- Function : Author
Laurent Costes
- Function : Author
Soraya Merbah
- Function : Author
Paul Carrier
- Function : Author
Maryline Debette-Gratien
- Function : Author
Jérémie Jacques
- Function : Author
Guillaume Lassailly
- Function : Author
Florent Artu
- Function : Author
Valérie Canva
- Function : Author
Sébastie Dharancy
- Function : Author
Alexandre Louvet
- Function : Author
Marianne Latournerie
- Function : Author
Marc Bardou
- Function : Author
Thomas Mouillot
- Function : Author
Yannick Bacq
- Function : Author
Didier Barbereau
- Function : Author
Charlotte Nicolas
- Function : Author
Caroline Chevalier
- Function : Author
Isabelle Archambeaud
- Function : Author
Sarah Habes
- Function : Author
Nisserine Ben Amara
- Function : Author
Danièl Botta-Fridlund
- Function : Author
Eric Saillard
- Function : Author
Marie-José Lafrance
- Function : Author
Fabien Zoulim
- Function : Author
- PersonId : 890662
- IdHAL : fabien-zoulim
- ORCID : 0000-0002-2245-0083
Carole Cagnot
- Function : Author
Thomas Decaens
- Function : Author
Dominique Thabut
- Function : Author
Tarik Asselah
- Function : Author
Philippe Mathurin
- Function : Author
- PersonId : 903127
- ORCID : 0000-0003-3447-2025
Nathalie Ganne
- Function : Author
Didier Samuel
- Function : Author
Françoi Habersetzer
- Function : Author
Jean-Pierre Bronowicki
- Function : Author
Dominique Guyader
- Function : Author
Isabelle Rosa
- Function : Author
Vincent Leroy
- Function : Author
Olivier Chazouilleres
- Function : Author
Victor De Ledinghen
- Function : Author
Marc Bourliere
- Function : Author
Xavier Causse
- Function : Author
Paul Cales
- Function : Author
- PersonId : 759545
- ORCID : 0000-0003-4866-5274
- IdRef : 06952680X
Sophie Metivier
- Function : Author
Véroniqu Loustaud-Ratti
- Function : Author
Armand Abergel
- Function : Author
- PersonId : 763073
- ORCID : 0000-0001-7480-1052
- IdRef : 109301269
Hélène Fontaine
- Function : Author
Abstract
Background: Chronic hepatitis B virus (HBV) infection results in a high risk of cirrhosis and its complications, cirrhosis decompensation (DC), hepatocellular carcinoma (HCC), liver transplantation (LT), death or any of these outcomes (composite endpoint [CE]). Nucleos(t)ide analogues (NUCs) such as tenofovir or entecavir are associated with a reduction in these complications.
Aim: To compare the impact of tenofovir and entecavir on these outcomes in patients treated for HBV infection and included in the prospective Hepather cohort.
Methods: All patients with HBV infection who had received tenofovir or entecavir for more than 6 months at or after entry in the ANRS CO22 cohort were selected. Patients with HDV and HCV co-infection or prior liver event were excluded. Incidence rates of events were compared using inverse probability of treatment weighting (IPW).
Results: The cohort included 1800 patients (986 tenofovir and 814 entecavir). Median follow-up was 4.2 years. The incidences of HCC, DC, LT, ACD, LRD and CE were not different between tenofovir- (1.8 (0.9; 3.2), 0.6 (0.2; 1.6), 0.2 (0.0; 0.8), 1.7 (0.8; 3.0), 0.8 (0.2, 1.8) and 4.1 (3.0; 5.4) per 1000 person-years) and entecavir-treated patients (1.6 (0.7; 3.0), 0.7 (0.2; 1.8), 0.2 (0.0; 1.0), 3.0 (1.7, 4.8), 0.5 (0.1; 1.5) and 5.0 (3.3; 7.2)) per 1000 person-years, respectively.
Conclusion: The risk of liver-related events or death was not different between tenofovir- and entecavir-treated patients in this large prospective cohort of predominantly non-cirrhotic French patients.
Trial registration number: NCT019553458.
Domains
Santé publique et épidémiologie
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Pol et Group - 2021 - Similar 5-year HCC occurrence in Tenofovir- and En.pdf (497.05 Ko)
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10.1111_apt.16661_2.pdf (131.07 Ko)
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