Infectious Complications in HIV-infected Kidney Transplant Recipients - Sorbonne Université
Journal Articles International Journal of STD & AIDS Year : 2018

Infectious Complications in HIV-infected Kidney Transplant Recipients

Abstract

Renal transplantation is now a viable alternative for dialysis in HIV-infected patients who achieve good immunovirological control with current antiretroviral therapy regimens available. However, there are few studies that analyze the incidence of post-transplant infections in this population. In this study, a retrospective analysis of data files of 24 HIV-infected kidney transplant (KT) recipients was undertaken, matched to 21 non-infected controls. All patients received induction with anti-interleukin-2 antibodies and were followed in the Pitié-Salpêtrière Hospital in Paris, France. The rate of incidence of post-transplant infections was 23.58 and 26.98/100 patient-years, in HIV-infected and HIV-negative groups (relative risk [RR]: 0.90; 95% confidence interval [CI]: 0.58\textendash 1.39; p\,=\,0.63). In HIV-infected KT recipients, bacterial infections were the most frequent (67.7%), followed by viral (14.7%) and fungal and parasitic infections (8.8%). Similar trends were seen in the control group. Incidence of opportunistic infections was similar in HIV-infected KT recipients and controls (38.2 vs. 26.5%; p\,=\,0.44). There were three post-transplant HIV reactivations in two patients, secondary to poor adherence to medication. HIV status did not influence survival, but infections increased the risk of unfavorable outcome. Incidence of post-transplant infections was similar in HIV-infected KT recipients and controls. Infections, but not HIV status, had adverse effects on patient and graft survival.
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Dates and versions

hal-03793418 , version 1 (01-10-2022)

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O Ailioaie, N Arzouk, Ma Valantin, J Tourret, Ro Calin, et al.. Infectious Complications in HIV-infected Kidney Transplant Recipients. International Journal of STD & AIDS, 2018, 29 (4), pp.341--349. ⟨10.1177/0956462417726213⟩. ⟨hal-03793418⟩
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