Mapping of HIV-1C Transmission Networks Reveals Extensive Spread of Viral Lineages Across Villages in Botswana Treatment-as-Prevention Trial - Sorbonne Université Access content directly
Journal Articles The Journal of Infectious Diseases Year : 2020

Mapping of HIV-1C Transmission Networks Reveals Extensive Spread of Viral Lineages Across Villages in Botswana Treatment-as-Prevention Trial

Tapiwa Nkhisang
  • Function : Author
Mary Fran Mclane
  • Function : Author
Jean Leidner
  • Function : Author
Kara Bennett
  • Function : Author
Lucie Abeler-Dörner
  • Function : Author
David Bonsall
  • Function : Author
Christophe Fraser
  • Function : Author
Tanya Golubchik
  • Function : Author
Helen Ayles
  • Function : Author
Rory Bowden
  • Function : Author
Sarah Fidler
  • Function : Author
Kate Grabowski
  • Function : Author
Joseph Kagaayi
  • Function : Author
Richard Hayes
  • Function : Author
Janet Seeley
  • Function : Author
Joshua Herbeck
  • Function : Author
Jairam Lingappa
  • Function : Author
Pontiano Kaleebu
  • Function : Author
Deogratius Ssemwanga
  • Function : Author
Deenan Pillay
  • Function : Author
Frank Tanser
  • Function : Author
Thomas Quinn
  • Function : Author
Andrew Rambaut
  • Function : Author
Andrew Leigh-Brown
  • Function : Author
Oliver Ratmann
  • Function : Author
Maria Wawer
  • Function : Author
Myron Cohen
  • Function : Author
Ann Dennis
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Tulio d'Oliveira
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Dan Frampton
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Anne Hoppe
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Paul Kellam
  • Function : Author
Cissy Kityo
  • Function : Author
Nick Paton
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Abstract

Abstract Background Phylogenetic mapping of HIV-1 lineages circulating across defined geographical locations is promising for better understanding HIV transmission networks to design optimal prevention interventions. Methods We obtained near full-length HIV-1 genome sequences from people living with HIV (PLWH), including participants on antiretroviral treatment in the Botswana Combination Prevention Project, conducted in 30 Botswana communities in 2013\textendash 2018. Phylogenetic relationships among viral sequences were estimated by maximum likelihood. Results We obtained 6078 near full-length HIV-1C genome sequences from 6075 PLWH. We identified 984 phylogenetically distinct HIV-1 lineages (molecular HIV clusters) circulating in Botswana by mid-2018, with 2\textendash 27 members per cluster. Of these, dyads accounted for 62%, approximately 32% (n\hspace0.25em=\hspace0.25em316) were found in single communities, and 68% (n\hspace0.25em=\hspace0.25em668) were spread across multiple communities. Men in clusters were approximately 3 years older than women (median age 42 years, vs 39 years; P\hspace0.25em<\hspace0.25em.0001). In 65% of clusters, men were older than women, while in 35% of clusters women were older than men. The majority of identified viral lineages were spread across multiple communities. Conclusions A large number of circulating phylogenetically distinct HIV-1C lineages (molecular HIV clusters) suggests highly diversified HIV transmission networks across Botswana communities by 2018.
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Dates and versions

hal-03793506 , version 1 (01-10-2022)

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Vlad Novitsky, Melissa Zahralban-Steele, Sikhulile Moyo, Tapiwa Nkhisang, Dorcas Maruapula, et al.. Mapping of HIV-1C Transmission Networks Reveals Extensive Spread of Viral Lineages Across Villages in Botswana Treatment-as-Prevention Trial. The Journal of Infectious Diseases, 2020, 222 (10), pp.1670--1680. ⟨10.1093/infdis/jiaa276⟩. ⟨hal-03793506⟩
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