Dynamic Amino Acid Side-Chains Grafting on Folded Peptide Backbone
Résumé
An efficient strategy for the synthesis of large libraries of conformationally defined peptides is reported, using dynamic combinatorial chemistry as a tool to graft amino acid side chains on a well-ordered 3D (3-dimension) peptide backbone. Combining rationally designed scaffolds with combinatorial side chains selection represents an alternative method to access peptide libraries for structures that are not genetically encodable. This method would allow a breakthrough for the discovery of protein mimetic for unconventional targets for which little is known.
Domaines
Chimie organique| Origine | Fichiers éditeurs autorisés sur une archive ouverte |
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