Loss of long-term non-progressor and HIV controller status over time in the French Hospital Database on HIV - ANRS CO4 - Sorbonne Université Access content directly
Journal Articles PLoS ONE Year : 2017

Loss of long-term non-progressor and HIV controller status over time in the French Hospital Database on HIV - ANRS CO4

Hana Selinger-Leneman
  • Function : Author
Sophie Abgrall
  • Function : Author
Gilles Pialoux
  • Function : Author
Laurence Weiss
  • Function : Author
Dominique Costagliola
  • Function : Author

Abstract

We studied the frequency and risk factors for loss of long-term non-progressor (LTNP) and HIV controller (HIC) status among patients identified as such in 2005 in the French Hospital Database on HIV (FHDH-ANRS CO4). Methods We selected patients who were treatment-naïve and asymptomatic in 2005 (baseline). Those with ≥8 years of known HIV infection and a CD4 cell nadir ≥500/mm 3 were classified as LTNP and those with ≥10 years of known HIV infection and 90% of plasma viral load (VL) values 500 copies/ml in the absence of cART as HIC. cART initiation without loss of status and death from non AIDS-defining causes were considered as competing events. Results After 5 years of follow-up, 33% (95%CI; 27-42) of 171 LTNP patients and 17% (95%CI; 10-30) of 72 HIC patients had lost their status. In multivariable analyses, loss of LTNP status was associated with lower baseline CD4 cell counts and CD4/CD8 ratios. Only VL was significantly associated with loss of HIC status after adjustment for the baseline CD4 cell count, the CD4/CD8 ratio, and concomitant LTNP status. The hazard ratio for loss of HIC status was 5.5 (95%CI, 1.5-20.1) for baseline VL 50-500 vs <50 cp/mL, after adjustment for the baseline CD4 cell count. Conclusions One-third of LTNP and one-fifth of HIC patients lost their status after 5 years of follow-up, raising questions as to the possible benefits and timing of ART initiation in these populations.
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hal-03811552 , version 1 (11-10-2022)

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Sophie Grabar, Hana Selinger-Leneman, Sophie Abgrall, Gilles Pialoux, Laurence Weiss, et al.. Loss of long-term non-progressor and HIV controller status over time in the French Hospital Database on HIV - ANRS CO4. PLoS ONE, 2017, 12 (10), pp.e0184441. ⟨10.1371/journal.pone.0184441⟩. ⟨hal-03811552⟩
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