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Journal Articles Eurosurveillance Year : 2020

Interim 2019/20 Influenza Vaccine Effectiveness: Six European Studies, September 2019 to January 2020

Angela Rose (1) , Esther Kissling (1) , Hanne-Dorthe Emborg (2) , Amparo Larrauri (3) , Jim Mcmenamin , Francisco Pozo (3) , Ramona Trebbien , Clara Mazagatos (3) , Heather Whitaker (4) , Marta Valenciano (1) , Hanne-Dorthe Emborg , Ramona Trebbien , Daniel Thomas Lopez , Tyra Grove Krause , France Alessandra Falchi , Shirley Masse , Ana-Maria Vilcu (5) , Cécile Souty (5) , Thierry Blanchon (5) , Titouan Launay (5) , Sylvie van Der Werf , Vincent Enouf , Sylvie Behillil , Bruno Lina , Martine Valette , Marta Valenciano , Alain Moren , Esther Kissling , Angela Rose , Pasi Penttinen , Silke Buda , Ute Preuss , Kristin Tolksdorf , Barbara Biere , Ralf Duerrwald , Maria Smallfield , Robert Koch Marianne Wedde , Lisa Domegan , Rachel Fiegenbaum , Joan O’donnell , Michael Joyce , Olga Levis , Claire Collins , Charlene Bennett , Joanne Moran , Grainne Tuite , Jeff Connell , Cillian De Gascun , Adam Meijer , Marit De Lange , Sharon van Den Brink , Frederika Dijkstra , Mariette Hooiveld , Ana Paula Rodrigues , Ausenda Machado , Baltazar Nunes , Irina Kislaya , Verónica Gomez , Inês Costa , Patrícia Conde , Paula Cristóvão , Pedro Pechirra , Raquel Guiomar , Mihaela Lazar , Carmen Maria Cherciu , Maria Elena Mihai , Elena Duca , Mihaela Catalina Luca , Maria Gradinaru , Izabela Loghin , Carmen Manciuc , Grațiela Tardei , Maria Nica , Simin-Aysel Florescu , Emanoil Ceausu , Amparo Larrauri , Clara Mazagatos , Francisco Pozo , Inmaculada Casas , Luis García Comas , María Esther Insua Marisquerena , Juan Carlos Galán , Mª Dolores Folgueira , Carmen Quiñones Rubio , Eva Martinez Ochoa , Miriam Blasco , Jaume Gimenez Duran , Juana Maria Vanrell , Jordi Reina , Daniel Castrillejo , Concha Delgado , Jesus Oliva , Miriam Latorre-Millán , Ana María Milagro , Antonio Rezusta , M. Amelia Fernández Sierra , Mercedes Pérez Ruiz , María del Mar Rodríguez , Jesús Castilla , Manuel García Cenoz , Itziar Casado , Iván Martínez-Baz , Carlos Gómez Ibañez , Nerea Iriarte , Ana Navascués , M Eugenia Portillo , Carmen Ezpeleta , Åsa Wiman , Theresa Enkirch , Diogo F.P. Marques , Rory Gunson , Chris Robertson , Simon Cottrell , Catherine Moore , Mark O’doherty , Jillian Johnston , Conall Mccaughey , Simon De Lusignan , Ivelina Yonova , Manasa Tripathy , Rachel Byford , Filipa Ferreria , Jamie Lopezbernal , Richard Pebody , Mary Sinnathamby , Heather Whitaker , Nick Andrews , Joanna Ellis , Praveen Sebastianpillai , Maria Zambon
Angela Rose
  • Function : Author
Jim Mcmenamin
  • Function : Author
Ramona Trebbien
  • Function : Author
Hanne-Dorthe Emborg
  • Function : Author
Ramona Trebbien
  • Function : Author
Daniel Thomas Lopez
  • Function : Author
Tyra Grove Krause
  • Function : Author
France Alessandra Falchi
  • Function : Author
Shirley Masse
  • Function : Author
Sylvie van Der Werf
  • Function : Author
Vincent Enouf
  • Function : Author
Sylvie Behillil
  • Function : Author
Bruno Lina
Martine Valette
  • Function : Author
  • PersonId : 837412
Marta Valenciano
  • Function : Author
Alain Moren
  • Function : Author
Esther Kissling
  • Function : Author
Angela Rose
  • Function : Author
Pasi Penttinen
  • Function : Author
Silke Buda
  • Function : Author
Ute Preuss
  • Function : Author
Kristin Tolksdorf
  • Function : Author
Barbara Biere
  • Function : Author
Ralf Duerrwald
  • Function : Author
Maria Smallfield
  • Function : Author
Robert Koch Marianne Wedde
  • Function : Author
Lisa Domegan
  • Function : Author
Rachel Fiegenbaum
  • Function : Author
Joan O’donnell
  • Function : Author
Michael Joyce
  • Function : Author
Olga Levis
  • Function : Author
Claire Collins
  • Function : Author
Charlene Bennett
  • Function : Author
Joanne Moran
  • Function : Author
Grainne Tuite
  • Function : Author
Jeff Connell
  • Function : Author
Cillian De Gascun
  • Function : Author
Adam Meijer
  • Function : Author
Marit De Lange
  • Function : Author
Sharon van Den Brink
  • Function : Author
Frederika Dijkstra
  • Function : Author
Mariette Hooiveld
  • Function : Author
Ana Paula Rodrigues
  • Function : Author
Ausenda Machado
  • Function : Author
Baltazar Nunes
  • Function : Author
Irina Kislaya
  • Function : Author
Verónica Gomez
  • Function : Author
Inês Costa
  • Function : Author
Patrícia Conde
  • Function : Author
Paula Cristóvão
  • Function : Author
Pedro Pechirra
  • Function : Author
Raquel Guiomar
  • Function : Author
Mihaela Lazar
  • Function : Author
Carmen Maria Cherciu
  • Function : Author
Maria Elena Mihai
  • Function : Author
Elena Duca
  • Function : Author
Mihaela Catalina Luca
  • Function : Author
Maria Gradinaru
  • Function : Author
Izabela Loghin
  • Function : Author
Carmen Manciuc
  • Function : Author
Grațiela Tardei
  • Function : Author
Maria Nica
  • Function : Author
Simin-Aysel Florescu
  • Function : Author
Emanoil Ceausu
  • Function : Author
Amparo Larrauri
  • Function : Author
Clara Mazagatos
  • Function : Author
Francisco Pozo
  • Function : Author
Inmaculada Casas
  • Function : Author
Luis García Comas
  • Function : Author
Juan Carlos Galán
  • Function : Author
Mª Dolores Folgueira
  • Function : Author
Carmen Quiñones Rubio
  • Function : Author
Eva Martinez Ochoa
  • Function : Author
Miriam Blasco
  • Function : Author
Jaume Gimenez Duran
  • Function : Author
Juana Maria Vanrell
  • Function : Author
Jordi Reina
  • Function : Author
Daniel Castrillejo
  • Function : Author
Concha Delgado
  • Function : Author
Jesus Oliva
  • Function : Author
Miriam Latorre-Millán
  • Function : Author
Ana María Milagro
  • Function : Author
Antonio Rezusta
  • Function : Author
M. Amelia Fernández Sierra
  • Function : Author
Mercedes Pérez Ruiz
  • Function : Author
María del Mar Rodríguez
  • Function : Author
Jesús Castilla
  • Function : Author
Manuel García Cenoz
  • Function : Author
Itziar Casado
  • Function : Author
Iván Martínez-Baz
  • Function : Author
Carlos Gómez Ibañez
  • Function : Author
Nerea Iriarte
  • Function : Author
Ana Navascués
  • Function : Author
M Eugenia Portillo
  • Function : Author
Carmen Ezpeleta
  • Function : Author
Åsa Wiman
  • Function : Author
Theresa Enkirch
  • Function : Author
Diogo F.P. Marques
  • Function : Author
Rory Gunson
  • Function : Author
Chris Robertson
  • Function : Author
Simon Cottrell
  • Function : Author
Catherine Moore
  • Function : Author
Mark O’doherty
  • Function : Author
Jillian Johnston
  • Function : Author
Conall Mccaughey
  • Function : Author
Simon De Lusignan
  • Function : Author
Ivelina Yonova
  • Function : Author
Manasa Tripathy
  • Function : Author
Rachel Byford
  • Function : Author
Filipa Ferreria
  • Function : Author
Jamie Lopezbernal
  • Function : Author
Richard Pebody
  • Function : Author
Mary Sinnathamby
  • Function : Author
Heather Whitaker
  • Function : Author
Nick Andrews
  • Function : Author
Joanna Ellis
  • Function : Author
Praveen Sebastianpillai
  • Function : Author
Maria Zambon
  • Function : Author

Abstract

Background Influenza A(H1N1)pdm09, A(H3N2) and B viruses were co-circulating in Europe between September 2019 and January 2020. Aim To provide interim 2019/20 influenza vaccine effectiveness (VE) estimates from six European studies, covering 10 countries and both primary care and hospital settings. Methods All studies used the test-negative design, although there were some differences in other study characteristics, e.g. patient selection, data sources, case definitions and included age groups. Overall and influenza (sub)type-specific VE was estimated for each study using logistic regression adjusted for potential confounders. Results There were 31,537 patients recruited across the six studies, of which 5,300 (17%) were cases with 5,310 infections. Most of these (4,466; 84%) were influenza A. The VE point estimates for all ages were 29% to 61% against any influenza in the primary care setting and 35% to 60% in hospitalised older adults (aged 65 years and over). The VE point estimates against A(H1N1)pdm09 (all ages, both settings) was 48% to 75%, and against A(H3N2) ranged from -58% to 57% (primary care) and -16% to 60% (hospital). Against influenza B, VE for all ages was 62% to 83% (primary care only). Conclusions Influenza vaccination is of continued benefit during the ongoing 2019/20 influenza season. Robust end-of-season VE estimates and genetic virus characterisation results may help understand the variability in influenza (sub)type-specific results across studies.

Dates and versions

hal-03863422 , version 1 (21-11-2022)

Identifiers

Cite

Angela Rose, Esther Kissling, Hanne-Dorthe Emborg, Amparo Larrauri, Jim Mcmenamin, et al.. Interim 2019/20 Influenza Vaccine Effectiveness: Six European Studies, September 2019 to January 2020. Eurosurveillance, 2020, 25 (10), ⟨10.2807/1560-7917.ES.2020.25.10.2000153⟩. ⟨hal-03863422⟩
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