Primary Cilia Influence Progenitor Function during Cortical Development - Sorbonne Université Accéder directement au contenu
Article Dans Une Revue Cells Année : 2022

Primary Cilia Influence Progenitor Function during Cortical Development

Fiona Francis

Résumé

Corticogenesis is an intricate process controlled temporally and spatially by many intrinsic and extrinsic factors. Alterations during this important process can lead to severe cortical malformations. Apical neuronal progenitors are essential cells able to self-amplify and also generate basal progenitors and/or neurons. Apical radial glia (aRG) are neuronal progenitors with a unique morphology. They have a long basal process acting as a support for neuronal migration to the cortical plate and a short apical process directed towards the ventricle from which protrudes a primary cilium. This antenna-like structure allows aRG to sense cues from the embryonic cerebrospinal fluid (eCSF) helping to maintain cell shape and to influence several key functions of aRG such as proliferation and differentiation. Centrosomes, major microtubule organising centres, are crucial for cilia formation. In this review, we focus on how primary cilia influence aRG function during cortical development and pathologies which may arise due to defects in this structure. Reporting and cataloguing a number of ciliary mutant models, we discuss the importance of primary cilia for aRG function and cortical development.
Fichier principal
Vignette du fichier
cells-11-02895-v2.pdf (2.02 Mo) Télécharger le fichier
Origine Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03872737 , version 1 (25-11-2022)

Identifiants

Citer

Donia Zaidi, Kaviya Chinnappa, Fiona Francis. Primary Cilia Influence Progenitor Function during Cortical Development. Cells, 2022, 11 (18), pp.2895. ⟨10.3390/cells11182895⟩. ⟨hal-03872737⟩
43 Consultations
52 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More