International Patient and Physician Consensus on a Psoriatic Arthritis Core Outcome Set for Clinical Trials - Sorbonne Université Access content directly
Journal Articles Annals of the Rheumatic Diseases Year : 2017

International Patient and Physician Consensus on a Psoriatic Arthritis Core Outcome Set for Clinical Trials

Judy A. Shea
  • Function : Author
Ying Ying Leung
  • Function : Author
Musaab Elmamoun
  • Function : Author
Kristina Callis Duffin
  • Function : Author
Willemina Campbell
  • Function : Author
Laura Coates
  • Function : Author
Lihi Eder
  • Function : Author
Oliver Fitzgerald
  • Function : Author
Dafna Gladman
  • Function : Author
Chris Lindsay
  • Function : Author
Bev Shea
  • Function : Author
Ingrid Steinkoenig
  • Function : Author

Abstract

OBJECTIVE: To identify a core set of domains (outcomes) to be measured in psoriatic arthritis (PsA) clinical trials that represent both patients' and physicians' priorities. METHODS: We conducted (1) a systematic literature review (SLR) of domains assessed in PsA; (2) international focus groups to identify domains important to people with PsA; (3) two international surveys with patients and physicians to prioritise domains; (4) an international face-to-face meeting with patients and physicians using the nominal group technique method to agree on the most important domains; and (5) presentation and votes at the Outcome Measures in Rheumatology (OMERACT) conference in May 2016. All phases were performed in collaboration with patient research partners. RESULTS: We identified 39 unique domains through the SLR (24 domains) and international focus groups (34 domains). 50 patients and 75 physicians rated domain importance. During the March 2016 consensus meeting, 12 patients and 12 physicians agreed on 10 candidate domains. Then, 49 patients and 71 physicians rated these domains' importance. Five were important to >70% of both groups: musculoskeletal disease activity, skin disease activity, structural damage, pain and physical function. Fatigue and participation were important to >70% of patients. Patient global and systemic inflammation were important to >70% of physicians. The updated PsA core domain set endorsed by 90% of OMERACT 2016 participants includes musculoskeletal disease activity, skin disease activity, pain, patient global, physical function, health-related quality of life, fatigue and systemic inflammation. CONCLUSIONS: The updated PsA core domain set incorporates patients' and physicians' priorities and evolving PsA research. Next steps include identifying outcome measures that adequately assess these domains.
Fichier principal
Vignette du fichier
673.full.pdf (973.52 Ko) Télécharger le fichier
Origin Publisher files allowed on an open archive

Dates and versions

hal-03879083 , version 1 (30-04-2024)

Identifiers

Cite

Ana-Maria Orbai, Maarten de Wit, Philip Mease, Judy A. Shea, Laure Gossec, et al.. International Patient and Physician Consensus on a Psoriatic Arthritis Core Outcome Set for Clinical Trials. Annals of the Rheumatic Diseases, 2017, 76 (4), pp.673--680. ⟨10.1136/annrheumdis-2016-210242⟩. ⟨hal-03879083⟩
19 View
0 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More