Impaired Skin Microvascular Endothelial Reactivity in Critically Ill COVID-19 Patients - Sorbonne Université Access content directly
Journal Articles Annals of Intensive Care Year : 2022

Impaired Skin Microvascular Endothelial Reactivity in Critically Ill COVID-19 Patients

Abstract

Background Some clinical and histological studies have reported that SARS-CoV-2 infection may damage the endothelium. However, the impact of this virus on endothelial function in vivo remains poorly characterized. In this single-center pilot observational study, we performed iontophoresis of acetylcholine coupled with Laser doppler to investigate microvascular endothelial reactivity in COVID-19 patients compared to patients with non-COVID-19 bacterial pneumonia (NCBP) patients. Results: During three consecutive months, 32 COVID-19 patients and 11 control NCBP patients with acute respiratory failure were included. The median age was 59 [50–68] and 69 [57–75] years in COVID-19 and NCBP groups, respectively (P = 0.11). There was no significant difference in comorbidities or medications between the two groups, except for body mass index, which was higher in COVID-19 patients. NCBP patients had a higher SAPS II score compared to COVID-19 patients (P < 0.0001), but SOFA score was not different between groups (P = 0.51). Global hemodynamic and peripheral tissue perfusion parameters were not different between groups. COVID-19 patients had significantly lower skin microvascular basal blood flow than NCBP patients (P = 0.02). In addition, endothelium-dependent microvascular reactivity was threefold lower in COVID-19 patients than NCBP patients (P = 0.008). Conclusions Both baseline skin microvascular blood flow and skin endothelial-dependent microvascular reactivity were impaired in critically ill COVID-19 patients compared to NCBP patients, despite a lower disease severity score supporting a specific pathogenic role of SARS-CoV-2 on the endothelium.
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Dates and versions

hal-03879096 , version 1 (05-12-2022)

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Lisa Raia, Tomas Urbina, Paul Gabarre, Vincent Bonny, Geoffroy Hariri, et al.. Impaired Skin Microvascular Endothelial Reactivity in Critically Ill COVID-19 Patients. Annals of Intensive Care, 2022, 12 (1), pp.51. ⟨10.1186/s13613-022-01027-3⟩. ⟨hal-03879096⟩
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