Fetal Brain Injury Associated with Parvovirus B19 Congenital Infection Requiring Intrauterine Transfusion - Sorbonne Université Access content directly
Journal Articles Fetal Diagnosis and Therapy Year : 2019

Fetal Brain Injury Associated with Parvovirus B19 Congenital Infection Requiring Intrauterine Transfusion

Abstract

\textbf\emphBackground: Infection with parvovirus B19 (B19V) during pregnancy may cause severe fetal anemia, hydrops, and fe tal death. Furthermore, neurodevelopmental impairment among survivors may occur despite appropriate prenatal management, including intrauterine transfusion (IUT). \textbf\emphObjectives: Our primary objective was to describe cerebral lesions on MRI in fetuses with severe anemia requiring IUT for B19V infection. Our secondary objective was to search for clinical and biological characteristics associated with the occurrence of such lesions. \textbf\emphStudy Design: We performed a retrospective review of data on fetuses infected with B19V and requiring at least one IUT between 2005 and 2016. Fetuses with abnormal cerebral MRI results in the 3rd trimester were compared to those with normal MRI results. \textbf\emphResults: Of 34 transfused fetuses, 26 children were born at full term. Five intrauterine fetal deaths, 1 neonatal death, and 2 terminations of pregnancy occurred. Cerebral anomalies were observed in 7/27 fetuses on MRI, including cerebellar hemorrhage or a small cerebellum. Only viral load in fetal blood appeared to be associated with brain lesions (11.5 log\textsubscript10 copies/mL [10.5\textendash 12.5] in case of abnormal MRI results vs. 9.5 log\textsubscript10 copies/mL [7.8\textendash 10.0]; \emphp = 0.05). \textbf\emphConclusions: Among the fetuses transfused for B19V infection, 26% presented with prenatal abnormal cerebral imaging results. In our study, viral load in fetal blood appeared to be the only factor associated with fetal brain lesions.
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Dates and versions

hal-03886726 , version 1 (06-12-2022)

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Emeline Maisonneuve, Catherine Garel, Stéphanie Friszer, Cécile Penager, Bruno Carbonne, et al.. Fetal Brain Injury Associated with Parvovirus B19 Congenital Infection Requiring Intrauterine Transfusion. Fetal Diagnosis and Therapy, 2019, 46 (1), pp.1--11. ⟨10.1159/000489881⟩. ⟨hal-03886726⟩
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