COVID-19 in Pregnant Women With Rheumatic Disease: Data From the COVID-19 Global Rheumatology Alliance
Bonnie L. Bermas
(1)
,
Milena Gianfrancesco
(2)
,
Helen L. Tanner
(3)
,
Andrea M. Seet
(2)
,
Mathia C. Aguiar
(4)
,
Nasra K. Al Adhoubi
(5)
,
Samar Al Emadi
(6)
,
Bernardo M. Cunha
,
Rachael Flood
(7)
,
Daria A. Kusevich
,
Eoghan M. Mccarthy
(8)
,
Naomi J. Patel
(9)
,
Eric M. Ruderman
(10)
,
Sebastian E. Sattui
(11)
,
Savino Sciascia
(12)
,
Faizah Siddique
(13)
,
Maria O. Valenzuela-Almada
(14)
,
Leanna M. Wise
(15)
,
Angus B. Worthing
(16)
,
Joann Zell
(17)
,
Suleman Bhana
,
Wendy Costello
,
Ali Duarte-Garcia
(14)
,
Rebecca Grainger
(18)
,
Laure Gossec
(19, 20)
,
Jonathan S. Hausmann
(21)
,
Kimme Hyrich
(22)
,
Saskia Lawson-Tovey
(22)
,
Jean W. Liew
(23)
,
Emily Sirotich
(24)
,
Jeffrey A. Sparks
(25)
,
Paul Sufka
,
Zachary S. Wallace
(26)
,
Pedro M. Machado
(27)
,
Anja Strangfeld
(28)
,
Megan E.B. Clowse
(29)
,
Jinoos Yazdany
(2)
,
Philip C. Robinson
(3)
1
University of Texas Southwestern Medical Center [Dallas]
2 UC - University of California
3 UQ [All campuses : Brisbane, Dutton Park Gatton, Herston, St Lucia and other locations] - The University of Queensland
4 Hospital General Agustín O’Horán [Merida, Mexico]
5 RH - Royal Hospital [Muscat, Oman]
6 Hamad Medical Corporation [Doha, Qatar]
7 Tallaght Hospital
8 MFT - Manchester University NHS Foundation Trust
9 Massachusetts General Hospital [Boston]
10 Feinberg School of Medicine
11 Hospital for Special Surgery
12 OSGB - Ospedale San Giovanni Bosco [Turin, Italy]
13 LUMC - Loyola University Medical Center
14 Mayo Clinic [Rochester]
15 USC - University of Southern California
16 Georgetown University Medical Center
17 University of Colorado Anschutz [Aurora]
18 University of Otago [Dunedin, Nouvelle-Zélande]
19 CHU Pitié-Salpêtrière [AP-HP]
20 iPLESP - Institut Pierre Louis d'Epidémiologie et de Santé Publique
21 BIDMC - Beth Israel Deaconess Medical Center [Boston]
22 University of Manchester [Manchester]
23 BUSM - Boston University School of Medicine
24 McMaster University [Hamilton, Ontario]
25 Brigham and Women's Hospital [Boston]
26 HMS - Harvard Medical School [Boston]
27 LNWH - London North West University Healthcare NHS Trust
28 DRFZ - Deutsches Rheuma-ForschungsZentrum
29 Duke University School of Medicine [Durham, NC, USA]
2 UC - University of California
3 UQ [All campuses : Brisbane, Dutton Park Gatton, Herston, St Lucia and other locations] - The University of Queensland
4 Hospital General Agustín O’Horán [Merida, Mexico]
5 RH - Royal Hospital [Muscat, Oman]
6 Hamad Medical Corporation [Doha, Qatar]
7 Tallaght Hospital
8 MFT - Manchester University NHS Foundation Trust
9 Massachusetts General Hospital [Boston]
10 Feinberg School of Medicine
11 Hospital for Special Surgery
12 OSGB - Ospedale San Giovanni Bosco [Turin, Italy]
13 LUMC - Loyola University Medical Center
14 Mayo Clinic [Rochester]
15 USC - University of Southern California
16 Georgetown University Medical Center
17 University of Colorado Anschutz [Aurora]
18 University of Otago [Dunedin, Nouvelle-Zélande]
19 CHU Pitié-Salpêtrière [AP-HP]
20 iPLESP - Institut Pierre Louis d'Epidémiologie et de Santé Publique
21 BIDMC - Beth Israel Deaconess Medical Center [Boston]
22 University of Manchester [Manchester]
23 BUSM - Boston University School of Medicine
24 McMaster University [Hamilton, Ontario]
25 Brigham and Women's Hospital [Boston]
26 HMS - Harvard Medical School [Boston]
27 LNWH - London North West University Healthcare NHS Trust
28 DRFZ - Deutsches Rheuma-ForschungsZentrum
29 Duke University School of Medicine [Durham, NC, USA]
Bernardo M. Cunha
- Fonction : Auteur
Daria A. Kusevich
- Fonction : Auteur
Suleman Bhana
- Fonction : Auteur
Wendy Costello
- Fonction : Auteur
Paul Sufka
- Fonction : Auteur
Résumé
Objective To describe coronavirus disease 2019 (COVID-19) and pregnancy outcomes in patients with rheumatic disease who were pregnant at the time of infection. Methods Since March 2020, the COVID-19 Global Rheumatology Alliance has collected cases of patients with rheumatic disease with COVID-19. We report details of pregnant women at the time of COVID-19 infection, including obstetric details separately ascertained from providers. Results We report on 39 patients, including 22 with obstetric detail available. The mean and median age was 33 years, range 24\textendash 45 years. Rheumatic disease diagnoses included rheumatoid arthritis (n = 9), systemic lupus erythematosus (n = 9), psoriatic arthritis/other inflammatory arthritides (n = 8), and antiphospholipid syndrome (n = 6). Most had a term birth (16/22), with 3 preterm births, 1 termination, and 1 miscarriage; 1 woman had yet to deliver at the time of report. One-quarter (n = 10/39) of pregnant women were hospitalized following COVID-19 diagnosis. Two of 39 (5%) required supplemental oxygen (both hospitalized); no patients died. The majority did not receive specific medication treatment for their COVID-19 (n = 32/39, 82%), and 7 patients received some combination of antimalarials, colchicine, anti\textendash interleukin 1β, azithromycin, glucocorticoids, and lopinavir/ritonavir. Conclusion Women with rheumatic diseases who were pregnant at the time of COVID-19 had favorable outcomes. These data have limitations due to the small size and methodology; however, they provide cautious optimism for pregnancy outcomes for women with rheumatic disease particularly in comparison to the increased risk of poor outcomes that have been reported in other series of pregnant women with COVID-19.