Flare in Axial Spondyloarthritis: Investigation of Meaningful Changes in Symptomatic Outcome Measures - Sorbonne Université Access content directly
Journal Articles Clinical and Experimental Rheumatology Year : 2017

Flare in Axial Spondyloarthritis: Investigation of Meaningful Changes in Symptomatic Outcome Measures

Abstract

OBJECTIVES: To assess symptomatic outcomes associated with flare after discontinuation of non-steroidal anti-inflammatory drugs (NSAIDs) in axial spondyloarthritis (axSpA). METHODS: Patients with NSAID-refractory axSpA discontinued NSAIDs, restarted if symptoms recurred, and self-recorded Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). 75th percentiles were calculated for changes in BASDAI total and components from NSAID discontinuation to resumption. RESULTS: 75th percentiles for absolute/relative changes: BASDAI total (0-10)=1.5/28%; fatigue=2.0/25%; spinal pain=2.0/33%; joint pain/swelling=2.0/50%; enthesitis=2.0/43%; morning stiffness=1.5/27%. CONCLUSIONS: No single score threshold applied but absolute change ≥q2 or relative change ≥q30% indicated symptomatic deterioration for most BASDAI components.
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Dates and versions

hal-03894265 , version 1 (12-12-2022)

Identifiers

  • HAL Id : hal-03894265 , version 1
  • PUBMED : 27749225

Cite

Maxime Dougados, Emily Wood, Laure Gossec, Désirée van Der Heijde, Isabelle Logeart. Flare in Axial Spondyloarthritis: Investigation of Meaningful Changes in Symptomatic Outcome Measures. Clinical and Experimental Rheumatology, 2017, 35 (2), pp.209--213. ⟨hal-03894265⟩
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