SARS-CoV-2 Induces Cytokine Responses in Human Basophils - Sorbonne Université Access content directly
Journal Articles Frontiers in Immunology Year : 2022

SARS-CoV-2 Induces Cytokine Responses in Human Basophils

Abstract

Basophils play a key role in the orientation of immune responses. Though the interaction of SARS-CoV-2 with various immune cells has been relatively well studied, the response of basophils to this pandemic virus is not characterized yet. In this study, we report that SARS-CoV-2 induces cytokine responses and in particular IL-13, in both resting and IL-3 primed basophils. The response was prominent under IL-3 primed condition. However, either SARS-CoV-2 or SARS-CoV-2-infected epithelial cells did not alter the expression of surface markers associated with the activation of basophils, such as CD69, CD13 and/or degranulation marker CD107a. We also validate that human basophils are not permissive to SARS-CoV-2 replication. Though increased expression of immune checkpoint molecule PD-L1 has been reported on the basophils from COVID-19 patients, we observed that SARS-CoV-2 does not induce PD-L1 on the basophils. Our data suggest that basophil cytokine responses to SARS-CoV-2 might help in reducing the inflammation and also to promote antibody responses to the virus.

Dates and versions

hal-03905104 , version 1 (17-12-2022)

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Srinivasa Reddy Bonam, Camille Chauvin, Laurine Levillayer, Mano Joseph Mathew, Anavaj Sakuntabhai, et al.. SARS-CoV-2 Induces Cytokine Responses in Human Basophils. Frontiers in Immunology, 2022, 13, ⟨10.3389/fimmu.2022.838448⟩. ⟨hal-03905104⟩
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