Optimal combination of early biomarkers for infection and sepsis diagnosis in the emergency department: The BIPS study - Sorbonne Université
Journal Articles Journal of Infection Year : 2021

Optimal combination of early biomarkers for infection and sepsis diagnosis in the emergency department: The BIPS study

Abstract

Objective: : To define the best combination of biomarkers for the diagnosis of infection and sepsis in the emergency room. Methods: : In this prospective study, consecutive patients with a suspicion of infection in the emergency room were included. Eighteen different biomarkers measured in plasma, and twelve biomarkers measured on monocytes, neutrophils, B and T-lymphocytes were studied and the best combinations determined by a gradient tree boosting approach. Results: : Overall, 291 patients were included and analysed, 148 with bacterial infection, and 47 with viral infection. The best biomarker combination which first allowed the diagnosis of bacterial infection, included HLA-DR (human leukocyte antigen DR) on monocytes, MerTk (Myeloid-epithelial-reproductive tyrosine kinase) on neutrophils and plasma metaloproteinase-8 (MMP8) with an area under the curve (AUC) = 0.94 [95% confidence interval (IC95): 0.91;0.97]. Among patients in whom a bacterial infection was excluded, the combination of CD64 expression, and CD24 on neutrophils and CX3CR1 on monocytes ended to an AUC = 0.98 [0.96;1] to define those with a viral infection. Conclusion: : In a convenient cohort of patients admitted with a suspicion of infection, two different combinations of plasma and cell surface biomarkers were performant to identify bacterial and viral infection.
Fichier principal
Vignette du fichier
BIPS in press.pdf (1.2 Mo) Télécharger le fichier
Origin Publisher files allowed on an open archive

Dates and versions

hal-03920162 , version 1 (14-02-2023)

Identifiers

Cite

Laetitia Velly, Steven Volant, Catherine Fitting, Daniel Aiham Ghazali, Florian Salipante, et al.. Optimal combination of early biomarkers for infection and sepsis diagnosis in the emergency department: The BIPS study. Journal of Infection, 2021, 82 (4), pp.11-21. ⟨10.1016/j.jinf.2021.02.019⟩. ⟨hal-03920162⟩
22 View
151 Download

Altmetric

Share

More