A Novel Role of Semaphorin 3C in Modulating Systemic and Renal Hemodynamics - Sorbonne Université
Journal Articles Nephron Physiology Year : 2022

A Novel Role of Semaphorin 3C in Modulating Systemic and Renal Hemodynamics

Abstract

Background: Alterations of renal hemodynamics play an essential role in renal homeostasis and kidney diseases. Recent data indicated that semaphorin 3C (SEMA3C), a secreted glycoprotein involved in vessel development, can modulate renal vascular permeability in acute kidney injury, but whether and how it might impact systemic and renal hemodynamics is unknown. Objectives: The objective of the study was to explore the effect of SEMA3C on systemic and renal hemodynamics. Methods: SEMA3C recombinant protein was administered intravenously in two-month-old wild-type mice, and the variations of mean arterial pressure, heart rate, renal blood flow, and renal vascular resistance were measured and analyzed. Results: Acute administration of SEMA3C induced (i) systemic hemodynamic changes, including mean arterial pressure decrease and heart rate augmentation; (ii) renal hemodynamic changes, including reduced vascular resistance and elevated renal blood flow. Continuous perfusion of SEMA3C had no significant effect on systemic or renal hemodynamics. Conclusion: SEMA3C is a potent vasodilator affecting both systemic and renal hemodynamics in mice.
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hal-03922943 , version 1 (25-02-2023)

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Anxiang Cai, Sandrine Placier, Liliane Louedec, Perrine Frère, Souhila Ouchelouche, et al.. A Novel Role of Semaphorin 3C in Modulating Systemic and Renal Hemodynamics. Nephron Physiology, 2022, pp.1-7. ⟨10.1159/000528259⟩. ⟨hal-03922943⟩
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