PARP Inhibitor Inhibits the Vasculogenic Mimicry through a NF-κB-PTX3 Axis Signaling in Breast Cancer Cells - Sorbonne Université Access content directly
Journal Articles International Journal of Molecular Sciences Year : 2022

PARP Inhibitor Inhibits the Vasculogenic Mimicry through a NF-κB-PTX3 Axis Signaling in Breast Cancer Cells

Justine Chivot
  • Function : Author
Nathalie Ferrand
  • Function : Author
Aude Fert
  • Function : Author
Patrick van Dreden
Romain Morichon

Abstract

Poly (ADP-ribose) polymerase inhibitors (PARPi) are targeted therapies that inhibit PARP proteins which are involved in a variety of cell functions. PARPi may act as modulators of angiogenesis; however, the relationship between PARPi and the vasculogenic mimicry (VM) in breast cancer remains unclear. To determine whether PARPi regulate the vascular channel formation, we assessed whether the treatment with olaparib, talazoparib and veliparib inhibits the vascular channel formation by breast cancer cell lines. Here, we found that PARPi act as potent inhibitors of the VM formation in triple negative breast cancer cells, independently of the BRCA status. Mechanistically, we find that PARPi trigger and inhibit the NF-κB signaling, leading to the inhibition of the VM. We further show that PARPi decrease the expression of the angiogenic factor PTX3. Moreover, PTX3 rescued the PARPi-inhibited VM inhibition. In conclusion, our results indicate that PARPi, by targeting the VM, may provide a new therapeutic approach for triple negative breast cancer.
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Dates and versions

hal-03924463 , version 1 (05-01-2023)

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Justine Chivot, Nathalie Ferrand, Aude Fert, Patrick van Dreden, Romain Morichon, et al.. PARP Inhibitor Inhibits the Vasculogenic Mimicry through a NF-κB-PTX3 Axis Signaling in Breast Cancer Cells. International Journal of Molecular Sciences, 2022, 23, ⟨10.3390/ijms232416171⟩. ⟨hal-03924463⟩
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