The oncolytic virus Delta-24-RGD elicits an antitumor effect in pediatric glioma and DIPG mouse models - Sorbonne Université Access content directly
Journal Articles Nature Communications Year : 2019

The oncolytic virus Delta-24-RGD elicits an antitumor effect in pediatric glioma and DIPG mouse models

Marisol González-Huarriz
  • Function : Author
Montse Puigdelloses
  • Function : Author
Marta Zalacaín
  • Function : Author
Lucía Marrodán
  • Function : Author
Virginia Laspidea
  • Function : Author
Jose Javier Aristu
  • Function : Author
Luis Isaac Ramos
  • Function : Author
Jose A Martínez-Climent
  • Function : Author
Maria Jose García-Barchino
  • Function : Author
Eric Raabe
Michelle Monje
Oren J Becher
  • Function : Author
Marie Pierre Junier
Herve Chneiweiss
Guillermo Aldave
  • Function : Author
Hong Jiang
Juan Fueyo
  • Function : Author
Ana Patiño-García
Candelaria Gomez-Manzano
  • Function : Author
Marta M Alonso

Abstract

Abstract Pediatric high-grade glioma (pHGG) and diffuse intrinsic pontine gliomas (DIPGs) are aggressive pediatric brain tumors in desperate need of a curative treatment. Oncolytic virotherapy is emerging as a solid therapeutic approach. Delta-24-RGD is a replication competent adenovirus engineered to replicate in tumor cells with an aberrant RB pathway. This virus has proven to be safe and effective in adult gliomas. Here we report that the administration of Delta-24-RGD is safe in mice and results in a significant increase in survival in immunodeficient and immunocompetent models of pHGG and DIPGs. Our results show that the Delta-24-RGD antiglioma effect is mediated by the oncolytic effect and the immune response elicited against the tumor. Altogether, our data highlight the potential of this virus as treatment for patients with these tumors. Of clinical significance, these data have led to the start of a phase I/II clinical trial at our institution for newly diagnosed DIPG (NCT03178032).

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Cancer
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Dates and versions

hal-03941202 , version 1 (16-01-2023)

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Naiara Martínez-Vélez, Marc Garcia-Moure, Miguel Marigil, Marisol González-Huarriz, Montse Puigdelloses, et al.. The oncolytic virus Delta-24-RGD elicits an antitumor effect in pediatric glioma and DIPG mouse models. Nature Communications, 2019, 10 (1), pp.2235. ⟨10.1038/s41467-019-10043-0⟩. ⟨hal-03941202⟩
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