Invasive Fungal Rhinosinusitis Due to Co-infection with Mucormycosis and Exserohilum rostratum in a Patient with Acute Lymphoblastic Leukemia - Sorbonne Université Access content directly
Journal Articles Clinical Hematology International Year : 2022

Invasive Fungal Rhinosinusitis Due to Co-infection with Mucormycosis and Exserohilum rostratum in a Patient with Acute Lymphoblastic Leukemia

Vera Radici
  • Function : Author
Eolia Brissot
Suzanne Chartier
  • Function : Author
Bettina Fabiani
  • Function : Author
Mara Memoli
  • Function : Author
Anne Banet
  • Function : Author
Laurence Heuberger
  • Function : Author
Simona Lapusan
  • Function : Author
Sarah Atallah
  • Function : Author
Ollivier Legrand
  • Function : Author
Alexis Genthon

Abstract

Abstract Invasive fungal infections remain an important cause of complication and morbidity in the management of acute leukemias. Here we report the case of a 27-year-old patient from French Polynesia who was diagnosed with Philadelphia chromosome-negative B-cell acute lymphoblastic leukemia. After induction chemotherapy, she developed rhinosinusitis with extensive bone lysis. The context and clinical presentation quickly made us suspect an invasive mucormycosis infection. However, a multidisciplinary investigation including mass spectrometry techniques also revealed the presence of Exserohilum rostratum , a pathogen member of the genus Exserohilum that is ubiquitous in tropical and subtropical regions but rarely implicated in invasive sinusitis. Antifungal treatment combined with an early surgical approach resulted in a favorable clinical response.

Dates and versions

hal-03959419 , version 1 (27-01-2023)

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Cite

Vera Radici, Eolia Brissot, Suzanne Chartier, Juliette Guitard, Bettina Fabiani, et al.. Invasive Fungal Rhinosinusitis Due to Co-infection with Mucormycosis and Exserohilum rostratum in a Patient with Acute Lymphoblastic Leukemia. Clinical Hematology International, 2022, 4 (1-2), pp.60-64. ⟨10.1007/s44228-022-00009-3⟩. ⟨hal-03959419⟩
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