miR-1224 inhibits cell proliferation in acute liver failure by targeting the antiapoptotic gene Nfib
Mots clés
miR-1224 Acute liver failure Cell death Proliferation Biomarker Nfib Oxidative stress
miR-1224
Acute liver failure
Cell death
Proliferation
Biomarker
Nfib
Oxidative stress
miR-1224, acute liver failure, cell death, proliferation, biomarker, Nfib, oxidative stress ALF, Acute liver failure I/R, Ischemia-reperfusion miRNA, microRNA APAP, acetaminophen H 2 O 2 , Hydrogen peroxide CCl 4 , Carbon tetrachloride BrdU, 5-bromo-2'-deoxyuridine AUC, Area under curve SR, spontaneous recovery NSR, non- spontaneous recovery siRNA, small interfering RNA mRNA, messenger RNA qRT-PCR, quantitative real-time polymerase chain reaction AU, arbritary units H/R, hypoxia/regeneration TNF, tumor necrosis factor MTT, methyl thiazol tetrazolium cl. CASP-3, cleaved Caspase-3 GAPDH, glyceraldehyde-3-phosphate dehydrogenase UTR, untranslated region TUNEL, terminal deoxynucleotide transferase nick end labeling ROS, reactive oxygen species
miR-1224, acute liver failure, cell death, proliferation, biomarker, Nfib, oxidative stress ALF, Acute liver failure
I/R, Ischemia-reperfusion
miRNA, microRNA
APAP, acetaminophen
H 2 O 2 , Hydrogen peroxide
CCl 4 , Carbon tetrachloride
BrdU, 5-bromo-2'-deoxyuridine
AUC, Area under curve
SR, spontaneous recovery
NSR, non- spontaneous recovery
siRNA, small interfering RNA
mRNA, messenger RNA
qRT-PCR, quantitative real-time polymerase chain reaction
AU, arbritary units
H/R, hypoxia/regeneration
TNF, tumor necrosis factor
MTT, methyl thiazol tetrazolium
cl. CASP-3, cleaved Caspase-3
GAPDH, glyceraldehyde-3-phosphate dehydrogenase
UTR, untranslated region
TUNEL, terminal deoxynucleotide transferase nick end labeling
ROS, reactive oxygen species
Domaines
Sciences du Vivant [q-bio]Origine | Fichiers produits par l'(les) auteur(s) |
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