Blood ammonia in patients with chronic liver diseases: A better defined role in clinical practice - Sorbonne Université Access content directly
Journal Articles Analytical Biochemistry Year : 2022

Blood ammonia in patients with chronic liver diseases: A better defined role in clinical practice

Abstract

Ammonia is one of the main players in the pathogenesis of hepatic encephalopathy (HE) in patients with chronic liver diseases. The usefulness of measuring ammonemia has been debated since many years. New data reveal that besides helping in the differential diagnosis of HE, ammonemia could be a prognostic marker not only in patients with HE, but also in patients without any neurological symptoms, suggesting a potential toxic role of ammonia beyond the brain. Finally, targeting ammonemia while monitoring therapeutic response could be a way to improve outcomes in patients with HE.
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hal-03980588 , version 1 (02-03-2023)

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Maxime Mallet, Victor Desplats, Charlotte Bouzbib, Philippe Sultanik, Imen Alioua, et al.. Blood ammonia in patients with chronic liver diseases: A better defined role in clinical practice. Analytical Biochemistry, 2022, 657, ⟨10.1016/j.ab.2022.114873⟩. ⟨hal-03980588⟩
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