Practical Review of Recognition and Management of Obesity and Lipohypertrophy in Human Immunodeficiency Virus Infection - Sorbonne Université
Journal Articles Clinical Infectious Diseases Year : 2017

Practical Review of Recognition and Management of Obesity and Lipohypertrophy in Human Immunodeficiency Virus Infection

Jordan Lake
  • Function : Author
Takara Stanley
  • Function : Author
Caroline Apovian
  • Function : Author
Shalendar Bhasin
  • Function : Author
Todd Brown
  • Function : Author
Judith Currier
  • Function : Author
Michael Dube
  • Function : Author
Julian Falutz
  • Function : Author
Steven Grinspoon
  • Function : Author
Giovanni Guaraldi
  • Function : Author
Esteban Martinez
  • Function : Author
Grace Mccomsey
  • Function : Author
Fred Sattler
  • Function : Author
Kristine Erlandson
  • Function : Author

Abstract

Background: Obesity and lipohypertrophy are common in treated human immunodeficiency virus (HIV) infection and contribute to morbidity and mortality among HIV-infected adults on antiretroviral therapy (ART). Methods: We present a consensus opinion on the diagnosis, clinical consequences, and treatment of excess adiposity in adults with treated HIV infection. Results: Obesity and lipohypertrophy commonly occur among HIV-infected adults on ART and may have overlapping pathophysiologies and/or synergistic metabolic consequences. Traditional, HIV-specific, and ART-specific risk factors all contribute. The metabolic and inflammatory consequences of excess adiposity are critical drivers of non-AIDS events in this population. Although promising treatment strategies exist, further research is needed to better understand the pathophysiology and optimal treatment of obesity and lipohypertrophy in the modern ART era. Conclusions: Both generalized obesity and lipohypertrophy are prevalent among HIV-infected persons on ART. Aggressive diagnosis and management are key to the prevention and treatment of end-organ disease in this population and critical to the present and future health of HIV-infected persons.

Dates and versions

hal-03982919 , version 1 (10-02-2023)

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Jordan Lake, Takara Stanley, Caroline Apovian, Shalendar Bhasin, Todd Brown, et al.. Practical Review of Recognition and Management of Obesity and Lipohypertrophy in Human Immunodeficiency Virus Infection. Clinical Infectious Diseases, 2017, 64 (10), pp.1422-1429. ⟨10.1093/cid/cix178⟩. ⟨hal-03982919⟩
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