Anti-Influenza Drug Discovery and Development: Targeting the Virus and Its Host by All Possible Means - Sorbonne Université Accéder directement au contenu
Article Dans Une Revue Advances in Experimental Medicine and Biology Année : 2021

Anti-Influenza Drug Discovery and Development: Targeting the Virus and Its Host by All Possible Means

Olivier Terrier

Résumé

Influenza infections remain a major and recurrent source of public health concern. Together with vaccines, antiviral drugs play a key role in the prevention and treatment of influenza virus infection and disease. Today, the number of antiviral molecules approved for the treatment of influenza is relatively limited and their use is threatened by the emergence of viral strains with resistance mutations. There is therefore a real need to expand the prophylactic and therapeutic arsenal. This chapter summarizes the state of the art in drug discovery and development for the treatment of influenza virus infections, with a focus on both virus-targeting and host-cell-targeting strategies. Novel antiviral strategies targeting other viral proteins or targeting the host cell, some of which are based on drug repurposing, may be used in combination to strengthen our therapeutic arsenal against this major pathogen.
Fichier principal
Vignette du fichier
Chapitre livre influenza antivirals-revised FINAL.pdf (3.26 Mo) Télécharger le fichier
Origine Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03990855 , version 1 (15-02-2023)

Identifiants

Citer

Olivier Terrier, Anny Slama-Schwok. Anti-Influenza Drug Discovery and Development: Targeting the Virus and Its Host by All Possible Means. Advances in Experimental Medicine and Biology, 2021, pp.195 - 218. ⟨10.1007/978-981-16-0267-2_8⟩. ⟨hal-03990855⟩
8 Consultations
25 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More