Baseline factors associated with self-reported disease flares following COVID-19 vaccination among adults with systemic rheumatic disease: results from the COVID-19 global rheumatology alliance vaccine survey - Sorbonne Université Access content directly
Journal Articles Rheumatology Year : 2022

Baseline factors associated with self-reported disease flares following COVID-19 vaccination among adults with systemic rheumatic disease: results from the COVID-19 global rheumatology alliance vaccine survey

Lisa Rider
Christine Parks
  • Function : Author
Jesse Wilkerson
  • Function : Author
Adam Schiffenbauer
  • Function : Author
Richard Kwok
Payam Noroozi Farhadi
  • Function : Author
Sarvar Nazir
  • Function : Author
Rebecca Ritter
  • Function : Author
Emily Sirotich
  • Function : Author
Kevin Kennedy
Maggie Larche
  • Function : Author
Mitchell Levine
  • Function : Author
Sebastian Sattui
Jean Liew
Carly Harrison
  • Function : Author
Tarin Moni
  • Function : Author
Aubrey Miller
  • Function : Author
Michael Putman
  • Function : Author
Jonathan Hausmann
  • Function : Author
Julia Simard
Jeffrey Sparks
Frederick Miller
  • Function : Author
Akpabio Akpabio
  • Function : Author
Deshire Alpizar-Rodriguez
  • Function : Author
Francis Berenbaum
Inita Bulina
  • Function : Author
Richard Conway
  • Function : Author
Aman Dev Singh
  • Function : Author
Eimear Duff
  • Function : Author
Karen Durrant
  • Function : Author
Tamer Gheita
  • Function : Author
Catherine Hill
  • Function : Author
Richard Howard
  • Function : Author
Bimba Hoyer
  • Function : Author
Evelyn Hsieh
  • Function : Author
Lina El Kibbi
  • Function : Author
Adam Kilian
  • Function : Author
Alfred Kim
  • Function : Author
David Liew
  • Function : Author
Chieh Lo
  • Function : Author
Bruce Miller
  • Function : Author
Serena Mingolla
  • Function : Author
Michal Nudel
  • Function : Author
Candace Palmerlee
  • Function : Author
Jasvinder Singh
  • Function : Author
Namrata Singh
  • Function : Author
Manuel Ugarte-Gil
  • Function : Author
John Wallace
  • Function : Author
Kristen Young
  • Function : Author
Suleman Bhana
  • Function : Author
Wendy Costello
  • Function : Author
Rebecca Grainger
  • Function : Author
Pedro Machado
  • Function : Author
Philip Robinson
  • Function : Author
Paul Sufka
  • Function : Author
Zachary Wallace
  • Function : Author
Jinoos Yazdany
  • Function : Author
Gary Foster
  • Function : Author
Lehana Thabane
  • Function : Author
Saskya Angevare
  • Function : Author
Richard Beesley
  • Function : Author
Eugenia Chock
  • Function : Author
Berk Degirmenci
  • Function : Author
Christele Felix
  • Function : Author
Shangyi Jin
  • Function : Author
Elsa Mateus
  • Function : Author
Andrea Peirce
  • Function : Author
Esra Sari
  • Function : Author
Robert Tseng
  • Function : Author
Leslie Wang
  • Function : Author
Erick Adrian Zamora
  • Function : Author

Abstract

Abstract Objective To examine the frequency of, and risk factors for, disease flare following COVID-19 vaccination in patients with systemic rheumatic disease (SRD). Methods An international study was conducted from 2 April to 16 August 2021, using an online survey of 5619 adults with SRD for adverse events following COVID-19 vaccination, including flares of disease requiring a change in treatment. We examined risk factors identified a priori based on published associations with SRD activity and SARS-CoV-2 severity, including demographics, SRD type, comorbidities, vaccine type, cessation of immunosuppressive medications around vaccination and history of reactions to non-COVID-19 vaccines, using multivariable logistic regression. Results Flares requiring a change in treatment following COVID-19 vaccination were reported by 4.9% of patients. Compared with rheumatoid arthritis, certain SRD, including systemic lupus erythematosus (OR 1.51, 95% CI 1.03, 2.20), psoriatic arthritis (OR 1.95, 95% CI 1.20, 3.18) and polymyalgia rheumatica (OR 1.94, 95% CI 1.08, 2.48) were associated with higher odds of flare, while idiopathic inflammatory myopathies were associated with lower odds for flare (OR 0.54, 95% CI 0.31–0.96). The Oxford-AstraZeneca vaccine was associated with higher odds of flare relative to the Pfizer-BioNTech vaccine (OR 1.44, 95% CI 1.07, 1.95), as were a prior reaction to a non-COVID-19 vaccine (OR 2.50, 95% CI 1.76, 3.54) and female sex (OR 2.71, 95% CI 1.55, 4.72). Conclusion SRD flares requiring changes in treatment following COVID-19 vaccination were uncommon in this large international study. Several potential risk factors, as well as differences by disease type, warrant further examination in prospective cohorts.

Dates and versions

hal-03995036 , version 1 (17-02-2023)

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Cite

Lisa Rider, Christine Parks, Jesse Wilkerson, Adam Schiffenbauer, Richard Kwok, et al.. Baseline factors associated with self-reported disease flares following COVID-19 vaccination among adults with systemic rheumatic disease: results from the COVID-19 global rheumatology alliance vaccine survey. Rheumatology, 2022, 61 (SI2), pp.SI143-SI150. ⟨10.1093/rheumatology/keac249⟩. ⟨hal-03995036⟩
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