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Journal Articles Frontiers in Pediatrics Year : 2021

Improvement in Asthma Symptoms and Pulmonary Function in Children After SARS-CoV-2 Outbreak

Abstract

Introduction: Little is known on the effect of SARS-CoV-2 circulation on asthma daily symptoms in children. We compared asthma exacerbations, asthma symptom control and lung function before and after SARS-CoV-2 outbreak in children. Methods: Retrospective study of children with persistent asthma referred for lung function testing. The second quarter of 2020 being a period with nearly no activity, we compared the activity between the first, third and fourth quarters of 2019 and 2020 (Q1-2019 vs. Q1-2020, Q3-2019 vs. Q3-2020 and Q4-2019 vs. Q4-2020). Results: We retrieved 1,871 files in 2019 and 1,548 in 2020. The whole population [2,165 (63.3%) boys] had a median [IQR] age of 9.7 [6.8;13.1] years. There was no difference in age, sex, and ethnicity between 2019 and 2020 populations. Asthma was better controlled during Q4-2020 compared to Q4-2019 ( P = 0.042), and there was a lower proportion of children with at least one exacerbation in the previous 3 months after the reopening, compared to the same period in 2019 ( P < 0.0001). Baseline FEV 1 (Z-score) recorded after the reopening was significantly higher (with less reversibility) compared to the same period before the epidemic ( P < 0.0001). Baseline FEV 1 /FVC (Z-score) was significantly higher during Q3-2020 compared to Q3-2019 ( P = 0.026), with fewer children having a significant reversibility ( P = 0.035). Discussion: We demonstrated a trend toward increased exacerbations just before the recognition of the epidemic, and fewer exacerbations, better asthma symptom control and improvement in the lung function of asthmatic children after the reopening.

Dates and versions

hal-03995888 , version 1 (18-02-2023)

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Jessica Taytard, Florence Coquelin, Nicole Beydon. Improvement in Asthma Symptoms and Pulmonary Function in Children After SARS-CoV-2 Outbreak. Frontiers in Pediatrics, 2021, 9 (5), pp.106388. ⟨10.3389/fped.2021.745611⟩. ⟨hal-03995888⟩
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