Alcohol consumption in relation to carotid subclinical atherosclerosis and its progression: results from a European longitudinal multicentre study - Sorbonne Université Access content directly
Journal Articles European Journal of Nutrition Year : 2021

Alcohol consumption in relation to carotid subclinical atherosclerosis and its progression: results from a European longitudinal multicentre study

Federica Laguzzi
  • Function : Author
Damiano Baldassarre
  • Function : Author
Fabrizio Veglia
  • Function : Author
Rona Strawbridge
  • Function : Author
Steve Humphries
  • Function : Author
Rainer Rauramaa
  • Function : Author
Andries Smit
  • Function : Author
Philippe Giral
  • Function : Author
Angela Silveira
  • Function : Author
Elena Tremoli
  • Function : Author
Anders Hamsten
  • Function : Author
Ulf de Faire
  • Function : Author
Paolo Frumento
  • Function : Author
Karin Leander
  • Function : Author

Abstract

Abstract Background/Aim The association between alcohol consumption and subclinical atherosclerosis is still unclear. Using data from a European multicentre study, we assess subclinical atherosclerosis and its 30-month progression by carotid intima-media thickness (C-IMT) measurements, and correlate this information with self-reported data on alcohol consumption. Methods Between 2002–2004, 1772 men and 1931 women aged 54–79 years with at least three risk factors for cardiovascular disease (CVD) were recruited in Italy, France, Netherlands, Sweden, and Finland. Self-reported alcohol consumption, assessed at baseline, was categorized as follows: none (0 g/d), very-low (0 − 5 g/d), low (> 5 to ≤ 10 g/d), moderate (> 10 to ≤ 20 g/d for women, > 10 to ≤ 30 g/d for men) and high (> 20 g/d for women, > 30 g/d for men). C-IMT was measured in millimeters at baseline and after 30 months. Measurements consisted of the mean and maximum values of the common carotids (CC), internal carotid artery (ICA), and bifurcations (Bif) and whole carotid tree. We used quantile regression to describe the associations between C-IMT measures and alcohol consumption categories, adjusting for sex, age, physical activity, education, smoking, diet, and latitude. Results Adjusted differences between median C-IMT values in different levels of alcohol consumption (vs. very-low) showed that moderate alcohol consumption was associated with lower C-IMT max [− 0.17(95%CI − 0.32; − 0.02)], and Bif-IMT mean [− 0.07(95%CI − 0.13; − 0.01)] at baseline and decreasing C-IMT mean [− 0.006 (95%CI − 0.011; − 0.000)], Bif-IMT mean [− 0.016(95%CI − 0.027; − 0.005)], ICA-IMT mean [− 0.009(95% − 0.016; − 0.002)] and ICA-IMT max [− 0.016(95%: − 0.032; − 0.000)] after 30 months. There was no evidence of departure from linearity in the association between alcohol consumption and C-IMT. Conclusion In this European population at high risk of CVD, findings show an inverse relation between moderate alcohol consumption and carotid subclinical atherosclerosis and its 30-month progression, independently of several potential confounders.

Dates and versions

hal-03998897 , version 1 (21-02-2023)

Identifiers

Cite

Federica Laguzzi, Damiano Baldassarre, Fabrizio Veglia, Rona Strawbridge, Steve Humphries, et al.. Alcohol consumption in relation to carotid subclinical atherosclerosis and its progression: results from a European longitudinal multicentre study. European Journal of Nutrition, 2021, 60 (1), pp.123-134. ⟨10.1007/s00394-020-02220-5⟩. ⟨hal-03998897⟩
9 View
0 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More