Reciprocal Multifaceted Interaction Between HDL (High-Density Lipoprotein) and Myocardial Infarction - Sorbonne Université Access content directly
Journal Articles Arteriosclerosis, Thrombosis, and Vascular Biology Year : 2019

Reciprocal Multifaceted Interaction Between HDL (High-Density Lipoprotein) and Myocardial Infarction

Andrei Sposito
  • Function : Author
José Carlos de Lima-Junior
  • Function : Author
Filipe Moura
  • Function : Author
Joaquim Barreto
  • Function : Author
Isabella Bonilha
  • Function : Author
Michele Santana
  • Function : Author
Vitor Virginio
  • Function : Author
Lufan Sun
  • Function : Author
Luiz Sergio F. Carvalho
  • Function : Author
Alexandre A.S. Soares
  • Function : Author
Wilson Nadruz
  • Function : Author
Steve Feinstein
  • Function : Author
Jerzy-Roch Nofer
  • Function : Author
Ilaria Zanotti
  • Function : Author
Alan Remaley
  • Function : Author

Abstract

Despite decades of therapeutic advances, myocardial infarction remains a leading cause of death worldwide. Recent studies have identified HDLs (high-density lipoproteins) as a potential candidate for mitigating coronary ischemia/reperfusion injury via a broad spectrum of signaling pathways. HDL ligands, such as S1P (sphingosine-1-phosphate), Apo (apolipoprotein) A-I, clusterin, and miRNA, may influence the opening of the mitochondrial channel, insulin sensitivity, and production of vascular autacoids, such as NO, prostacyclin, and endothelin-1. In parallel, antioxidant activity and sequestration of oxidized molecules provided by HDL can attenuate the oxidative stress that triggers ischemia/reperfusion. Nevertheless, during myocardial infarction, oxidation and the capture of oxidized and proinflammatory molecules generate large phenotypic and functional changes in HDL, potentially limiting its beneficial properties. In this review, new findings from cellular and animal models, as well as from clinical studies, will be discussed to describe the cardioprotective benefits of HDL on myocardial infarction. Furthermore, mechanisms by which HDL modulates cardiac function and potential strategies to mitigate postmyocardial infarction risk damage by HDL will be detailed throughout the review.

Dates and versions

hal-03998926 , version 1 (21-02-2023)

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Andrei Sposito, José Carlos de Lima-Junior, Filipe Moura, Joaquim Barreto, Isabella Bonilha, et al.. Reciprocal Multifaceted Interaction Between HDL (High-Density Lipoprotein) and Myocardial Infarction. Arteriosclerosis, Thrombosis, and Vascular Biology, 2019, 39 (8), pp.1550-1564. ⟨10.1161/ATVBAHA.119.312880⟩. ⟨hal-03998926⟩
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