In familial Mediterranean fever, soluble TREM-1 plasma level is higher in case of amyloidosis - Sorbonne Université Access content directly
Journal Articles Innate Immunity Year : 2019

In familial Mediterranean fever, soluble TREM-1 plasma level is higher in case of amyloidosis

Abstract

We aimed to explore triggering receptor expressed on myeloid cells-1 (TREM-1) activation in familial Mediterranean fever (FMF), the most frequent monogenic auto-inflammatory disease, through the measurement of its serum soluble form, named sTREM-1. Blood samples from patients with FMF according to Livneh criteria followed in the French FMF national center and carrying two pathogenic MEFV mutations were collected. Serum level of sTREM-1 was assessed using ELISA. Demographic data, presence of FMF attack, association with histologically proven AA amyloidosis, and blood levels of C-reactive protein (CRP), serum amyloid A (SAA) protein, and creatinine were collected. TREM-1 was available in 56 patients (33.9% male, mean age 43 yr); AA amyloidosis was associated in six patients (19.6% in FMF). Mean sTREM-1 level did not differ significantly between patients having an attack or not and there was also no significant correlation between the level of sTREM-1 and CRP and SAA protein. However, the mean rate of sTREM-1 was significantly higher among FMF patients with AA amyloidosis versus without, though the concomitant SAA protein level was normal. Serum level of sTREM-1 was higher in patients with amyloidosis even though the concomitant SAA protein level was normal. sTREM-1 plasma levels could be an accurate tool to specifically identify FMF patients with amyloidosis.

Dates and versions

hal-04001161 , version 1 (22-02-2023)

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Clémence Gorlier, Jérémie Sellam, Ludivine Laurans, Tabassome Simon, Irina Giurgea, et al.. In familial Mediterranean fever, soluble TREM-1 plasma level is higher in case of amyloidosis. Innate Immunity, 2019, 25 (8), pp.487-490. ⟨10.1177/1753425919870847⟩. ⟨hal-04001161⟩
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