Conservative pattern of interaction of bat and human IgG antibodies with FcRn - Sorbonne Université Access content directly
Journal Articles Developmental and Comparative Immunology Year : 2023

Conservative pattern of interaction of bat and human IgG antibodies with FcRn

Abstract

Recently, numerous studies report bats as reservoirs of emerging pathogens with little to no signs of infections. This is thought to be connected to the unique immune system of bats, which remains poorly characterized. Despite the physiological importance of the Neonatal Fc receptor (FcRn) in the homeostasis of IgG antibodies, it is unclear how its functional activity is evolutionary conservative among mammals, and so is the case for bats. Using surface plasmon resonance-based technology, we tested the interactions of IgG antibodies isolated from three bat species with recombinant human and mouse FcRn. Our data show that IgG from the studied bat species binds to both human and mouse FcRn, albeit with distinct affinities. Importantly, the binding pattern of bat IgG is similar to human IgG. This confirms the conservative nature of IgG-FcRn interaction and highlights the importance of FcRn IgG salvaging system in bats.
Fichier principal
Vignette du fichier
Toshkova et al DCI.pdf (2.41 Mo) Télécharger le fichier
Origin Files produced by the author(s)

Dates and versions

hal-04020160 , version 1 (08-03-2023)

Identifiers

Cite

Nia Toshkova, Violeta Zhelyazkova, Sune Justesen, Jordan Dimitrov. Conservative pattern of interaction of bat and human IgG antibodies with FcRn. Developmental and Comparative Immunology, 2023, 139, pp.104579. ⟨10.1016/j.dci.2022.104579⟩. ⟨hal-04020160⟩
20 View
50 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More