Healthcare trajectory of critically ill patients with necrotizing soft tissue infections: a multicenter retrospective cohort study using the clinical data warehouse of Greater Paris University Hospitals - Sorbonne Université Access content directly
Journal Articles (Data Paper) Annals of Intensive Care Year : 2022

Healthcare trajectory of critically ill patients with necrotizing soft tissue infections: a multicenter retrospective cohort study using the clinical data warehouse of Greater Paris University Hospitals

Camille Hua
  • Function : Author
Quentin de Roux
  • Function : Author
Anatole Harrois
  • Function : Author
Nadia Anguel
  • Function : Author
Antoine Vieillard-Baron
Jean-Paul Mira
  • Function : Author
Tomas Urbina
  • Function : Author
Stéphane Gaudry
  • Function : Author
Matthieu Turpin
  • Function : Author
Charles Damoisel
  • Function : Author
Djillali Annane
Jean-Damien Ricard
  • Function : Author
Barbara Hersant
  • Function : Author
Armand Mekontso Dessap
Olivier Chosidow
  • Function : Author
Richard Layese
  • Function : Author
Nicolas de Prost
Romain Arrestier
  • Function : Author
Michael Atlan
  • Function : Author
Thomas Bauer
  • Function : Author
Romain Bosc
  • Function : Author
Guillaume Carteaux
  • Function : Author
Cyril Charron
  • Function : Author
Bernard Clair
  • Function : Author
Yves Cohen
  • Function : Author
Jacques Duranteau
  • Function : Author
Muriel Fartoukh
  • Function : Author
Samy Figueiredo
  • Function : Author
Nicholas Heming
  • Function : Author
Raphaël Lepeule
  • Function : Author
Eric Maury
  • Function : Author
Lionel Nakad
  • Function : Author
Keyvan Razazi
  • Function : Author
Alain Sautet
  • Function : Author
Sébastien Tanaka
  • Function : Author
Léa Satre-Buisson
  • Function : Author
Emmanuel Weiss
  • Function : Author
Paul-Louis Woerther
  • Function : Author

Abstract

Background Necrotizing skin and soft tissue infections (NSTIs) are rare but serious and rapidly progressive infections characterized by necrosis of subcutaneous tissue, fascia and even muscle. The care pathway of patients with NSTIs is poorly understood. A better characterization of the care trajectory of these patients and a better identification of patients at risk of a complicated evolution, requiring prolonged hospitalization, multiple surgical re-interventions, or readmission to the intensive care unit (ICU), is an essential prerequisite to improve their care. The main objective of this study is to obtain large-scale data on the care pathway of these patients. We performed a retrospective multicenter observational cohort study in 13 Great Paris area hospitals, including patients hospitalized between January 1, 2015 and December 31, 2019 in the ICU for surgically confirmed NSTIs. a bacteremia [aOR = 3.29 (1.14-9.52); p = 0.028] and a higher SAPS II score [aOR = 1.05 (1.02-1.07); p < 0.0001]. 62.3% of patients were re-hospitalized within 6 months. Conclusion In this retrospective multicenter study, we showed that patients with NSTI required complex management and are major consumers of care. Two-thirds of them underwent a complicated hospital course, associated with a higher SAPS II score, a polymicrobial NSTI and a bacteremia.
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Dates and versions

hal-04022293 , version 1 (09-03-2023)

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Camille Windsor, Camille Hua, Quentin de Roux, Anatole Harrois, Nadia Anguel, et al.. Healthcare trajectory of critically ill patients with necrotizing soft tissue infections: a multicenter retrospective cohort study using the clinical data warehouse of Greater Paris University Hospitals. Annals of Intensive Care, 2022, 12, ⟨10.1186/s13613-022-01087-5⟩. ⟨hal-04022293⟩
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