Umbilical cord-derived mesenchymal stromal cell therapy to prevent the development of neurodevelopmental disorders related to low birth weight. - Sorbonne Université Access content directly
Journal Articles Scientific Reports Year : 2023

Umbilical cord-derived mesenchymal stromal cell therapy to prevent the development of neurodevelopmental disorders related to low birth weight.

Masahiro Tsuji
  • Function : Author
Takeo Mukai
  • Function : Author
Yoshiaki Sato
  • Function : Author
Yasue Azuma
  • Function : Author
Saki Yamamoto
  • Function : Author
Atsuto Onoda
  • Function : Author
Tokiko Nagamura-Inoue
  • Function : Author
Jacques-Olivier Coq
  • Function : Author

Abstract

Low birth weight (LBW) increases the risk of neurodevelopmental disorders (NDDs) such as attention-deficit/hyperactive disorder and autism spectrum disorder, as well as cerebral palsy, for which no prophylactic measure exists. Neuroinflammation in fetuses and neonates plays a major pathogenic role in NDDs. Meanwhile, umbilical cord-derived mesenchymal stromal cells (UC-MSCs) exhibit immunomodulatory properties. Therefore, we hypothesized that systemic administration of UC-MSCs in the early postnatal period may attenuate neuroinflammation and thereby prevent the emergence of NDDs. The LBW pups born to dams subjected to mild intrauterine hypoperfusion exhibited a significantly lesser decrease in the monosynaptic response with increased frequency of stimulation to the spinal cord preparation from postnatal day 4 (P4) to P6, suggesting hyperexcitability, which was improved by intravenous administration of human UC-MSCs (1 × 105 cells) on P1. Three-chamber sociability tests at adolescence revealed that only LBW males exhibited disturbed sociability, which tended to be ameliorated by UC-MSC treatment. Other parameters, including those determined via open-field tests, were not significantly improved by UC-MSC treatment. Serum or cerebrospinal fluid levels of pro-inflammatory cytokines were not elevated in the LBW pups, and UC-MSC treatment did not decrease these levels. In conclusion, although UC-MSC treatment prevents hyperexcitability in LBW pups, beneficial effects for NDDs are marginal.

Dates and versions

hal-04030818 , version 1 (15-03-2023)

Identifiers

Cite

Masahiro Tsuji, Takeo Mukai, Yoshiaki Sato, Yasue Azuma, Saki Yamamoto, et al.. Umbilical cord-derived mesenchymal stromal cell therapy to prevent the development of neurodevelopmental disorders related to low birth weight.. Scientific Reports, 2023, 13 (1), pp.3841. ⟨10.1038/s41598-023-30817-3⟩. ⟨hal-04030818⟩
15 View
0 Download

Altmetric

Share

Gmail Facebook X LinkedIn More