Molecular cloning of mRNA sequences transiently induced during rat liver regeneration*1 - Sorbonne Université Access content directly
Journal Articles Experimental Cell Research Year : 1987

Molecular cloning of mRNA sequences transiently induced during rat liver regeneration*1

Abstract

In order to isolate genes which are induced during liver regeneration, we have constructed a cDNA library from 16-h-regenerating liver poly(A)+ RNA. By computer analysis of autoradiograms produced by differential plaque hybridization with cDNA from normal or 16-h-regenerating liver, we have isolated several recombinant clones representing sequences transiently increased during liver regeneration. Three of these were further characterized: the level of the corresponding mRNAs increase rapidly after partial hepatectomy, before the onset of DNA synthesis. Two clones were identified as fibrinogen clones. It is speculated that alpha-fibrinogen may be involved in the growth process, or in its regulation.

Dates and versions

hal-04041375 , version 1 (22-06-2023)

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Joelle Sobczak, Anne-Marie Lotti, Philippe Taroux, Michel Duguet. Molecular cloning of mRNA sequences transiently induced during rat liver regeneration*1. Experimental Cell Research, 1987, 169 (1), pp.47-56. ⟨10.1016/0014-4827(87)90223-0⟩. ⟨hal-04041375⟩
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